Eosinophilic Dermatosis


Eosinophilic Dermatosis of Hematologic Malignancy (EDHM) is an uncommon skin disorder which may be easily misdiagnosed. Careful evaluation of the skin and lymph nodes with prompt referral to an oncologist for evaluation will hasten the diagnosis and treatment of Chronic Lymphocytic Leukemia (CLL) or other hematologic malignancy. Treatment of the underlying disease will resolve the annoying, chronic, recurrent, pruritic and painful “persistent insect-bite-like reactions” now named EDHM. We report a case of EDHM, which resolved following quick recognition of the skin condition and subsequent treatment of CLL with rituximab.

Leukemia cutis (LC) and eosinophilic dermatosis of hematologic malignancy (EDHM) are rare cutaneous manifestations of hematologic malignancies. Various therapeutic options are reported, with largely underwhelming responses. We present a patient with chronic leukemia (CLL) with concomitant LC and EDHM who was treated with dupilumab. Eosinophilic folliculitis (EF) might be an uncommon, intermittent dermatosis described by folliculocentric papules, pustules, or plaques influencing the top, trunk, and limits. It involves 4 subtypes: exemplary, puerile, HIV-related, and hematologic harm related EF. Analysis of EF in relationship with hematologic danger are frequently difficult because of variable morphologies and histopathologic findings. Here we portray a patient with EF in relationship with persistent myelomonocytic leukemia (CMML).

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Kathy Andrews
Journal Manager
Journal of Clinical & Experimental Dermatology Research
Email: dermatology@eclinicalsci.com