ICMR looks at COVID-19 vaccine launch

Image   Clinicians differ: Covaxin has ‘potential’, but it is unlikely to be ready by that time. A vaccine for COVID-19 from India is unlikely to be ready for public use by August 15 but early data on whether it is safe and proof of its working could be available by then, say clinicians involved with the trial. The vaccine candidate, called Covaxin, has been developed by Hyderabad-based, Bharat Biotech India Ltd (BBIL) who got approvals from the Drug Controller General of India on June 29 for phase-1 and phase-2 trials. The trials are done on groups of people... Read More

Clostridium difficile

Image Clostridium difficile (klos-TRID-e-um dif-uh-SEEL), also known as Clostridioides difficile and often referred to as C. difficile or C. diff, is a bacterium that can cause symptoms ranging from diarrhea to life-threatening inflammation of the colon. Illness from C. difficile most commonly affects older adults in hospitals or in long-term care facilities and typically occurs after use of antibiotic medications. However, studies show increasing rates of C. difficile infection among people traditionally not considered to be at high risk, such as young and healthy individuals who haven't used antibiotics and who haven't been in a health care facility. ... Read More

Liver Transplant

Image Liver transplantation or hepatic transplantation is the replacement of a diseased liver with the healthy liver from another person (allograft). Liver transplantation is a treatment option for end-stage liver disease and acute liver failure, although availability of donor organs is a major limitation. The most common technique is orthotopic transplantation, in which the native liver is removed and replaced by the donor organ in the same anatomic position as the original liver. The surgical procedure is complex, requiring careful harvest of the donor organ and meticulous implantation into the recipient. Liver transplantation is highly regulated, and only performed at designated transplant medical centers by highly trained transplant physicians and supporting... Read More

Kidney Transplant

Image Kidney transplantation or renal transplantation is the organ transplant of a kidney into a patient with end-stage kidney disease. Kidney transplantation is typically classified as deceased-donor (formerly known as cadaveric) or living-donor transplantation depending on the source of the donor organ. Living-donor kidney transplants are further characterized as genetically related (living-related) or non-related (living-unrelated) transplants, depending on whether a biological relationship exists between the donor and recipient. Exchanges and chains are a novel approach to expand the living donor pool. In February 2012, this novel approach to expand the living donor pool resulted in the largest chain in the world, involving 60 participants organized by the National Kidney Registry.... Read More

Soft Ticks as Parasites and Vectors

Image Soft ticks (Argasidae) constitute the second family of ticks in terms of diversity, including near 215 extant species. However, this account could be underestimated since from 2008 at least one species per year has been described. Studies on the biology (feeding habits, saliva, morphology), and systematics of these leathery parasites have provided insights to the understanding of tick evolution. Soft ticks are secretive parasites adapted to feeding on terrestrial vertebrates, including birds and bats, and are relevant for veterinary and human health. They can starve for years, and harbor a plethora of microorganisms, including the closest relatives to Coxiella burnetii;... Read More

Ticks and Host Immunity – New Strategies for Controlling Ticks and Tick-Borne Pathogens

Image The WHO informs that vector-borne diseases account for more than 17% of all infectious diseases of humans. Similarly, among the 117 diseases of animals listed by the OIE, 20 of them are transmitted by vectors. Ticks are second to mosquitoes as vectors of disease and, with almost 900 species world-wide, they are known to parasitize mammals, birds, reptiles, and amphibians. In many cases, there is a balance between host health and tick parasitism which appears to be due to co-evolution. The appearance of blood-feeding arthropods during evolution, therefore, represents a formidable selective pressure on defensive responses of vertebrate hosts. Furthermore,... Read More

Soil Transmitted Helminthiases and Schistosomiasis

Image With delayed treatment, schistosome and soil transmitted helminth (STH) infections in young children (<5 years)could potentially lead to irreversible lifelong detrimental health effects. This is because these infections are known tocause suboptimal growth and development in this critical phase of life. The present study sought to document theburden of schistosome and STH infections in TaitaTaveta County, Kenya, by determining the prevalence andintensity of the infections in children less than 5 years of age. The study also appraised the association betweeninfections with schistosomes, anaemia and nutritional status in children. A total of 132 children, 53.8% males, wereenrolled in the survey.... Read More

Illness of Stomach- Paediatric Giardiasis

Image Giardiasis, an illness that affects the digestive tract (stomach and intestines), is caused by a microscopic parasite called Giardia lamblia. The parasite attaches itself to the lining of the small intestines in humans, where it interferes with the body's absorption of fats and carbohydrates from digested foods. Giardia is one of the chief causes of diarrhea in the United States, and spreads through contaminated water. It can survive the normal amounts of chlorine used to purify community water supplies, and can live for more than 2 months in cold water. As few as 10 of the microscopic parasites... Read More

Cancer Antigen 125 Application and Test in Diagnosis of Pulmonary Tuberculosis

Image Pulmonary tuberculosis (TB) is a contagious bacterial infection thatattacks the lungs and spread to other organs. Globally, tuberculosisremains one of the leading causes of death and public health problems despite dramatic improvements made in providing access to high-quality TB services. WHO estimates that about one third of all incidentcases of active TB are not properly diagnosed or receive care of poorquality outside of national TB programs. Among diagnosed cases,the delay of the result is often long. Determination of diseaseactivity of pulmonary tuberculosis is important for treatment; butfollow-up of the infection activity and response to therapy is not always easy... Read More

Skin Disease~ Psoriasis

Image Psoriasis is a common skin condition that speeds up the life cycle of skin cells. It causes cells to build up rapidly on the surface of the skin. The extra skin cells form scales and red patches that are itchy and sometimes painful. Psoriasis is a chronic disease that often comes and goes. The main goal of treatment is to stop the skin cells from growing so quickly. There is no cure for psoriasis, but you can manage symptoms. Lifestyle measures, such as moisturizing, quitting smoking and managing stress, may help. Symptoms Psoriasis signs and symptoms are different for everyone.... Read More

Recent Advances in Generalized Pustular Psoriasis (GPP)

Image Generalized Pustular Psoriasis (GPP) is an enigmatic, chronic skin inflammatory disease, developing independently or in association with preexisting plaque psoriasis. Since the IL36RN mutation was revealed in some GPP cases in 2011, understanding of molecular patho-mechanisms of GPP has begun rapidly advancing in this decade. Namely, mutations/variants of IL36RN or CARD14 or AP1S3 have been found to be the cause of some GPP. Moreover, animal models of the disease have been developed recently and been analyzed to reveal immunological aspects of GPP. Meanwhile, many new medicines and therapies have also been developed and therapeutic management of this disorder is also... Read More

Pruritus Medicine

Image Chronic pruritus (CP) is defined by the presence of the sensation for at least 6 weeks according to the International Forum for the Study of Itch (IFSI). CP is described as a symptom of pruritogenic diseases such as inflammatory, infectious and autoimmune dermatoses, hepatobiliary and chronic kidney diseases, systemic and cutaneous lymphoma, solid neoplasms, neuropathic and psychic diseases. As a disease symptom, CP is highly prevalent in the population. Though CP parallels the onset of the causing disease, treatment of the underlying disease does not control, in most cases, the pruritus. In diabetes mellitus, for example, control of the metabolic... Read More

Endorsement of New Drugs

Image 1) Zeposia (ozanimod) Capsules Company: Bristol-Myers Squibb Company Date of Approval: March 25, 2020 Treatment for: Multiple Sclerosis Zeposia (ozanimod) is a sphingosine 1-phosphate receptor modulator indicated for the treatment of relapsing forms of multiple sclerosis (MS).   2) Isturisa (osilodrostat) Tablets Company: Novartis Pharmaceuticals Corporation Date of Approval: March 6, 2020 Treatment for: Cushing's Syndrome Isturisa (osilodrostat) is a cortisol synthesis inhibitor indicated for the treatment of adult patients with Cushing’s disease.   3) Durysta (bimatoprost) Implant Company: Allergan plc Date of Approval: March 3, 2020 Treatment for: Glaucoma (Open Angle), Intraocular Hypertension Durysta (bimatoprost implant) is a prostaglandin... Read More

Significance of General Medicines

Image There has been a spate of drug related illnesses and deaths reported from Pakistan in the press this year. In November, at least 17 people died in the eastern city of Lahore after drinking toxic cough syrup. Earlier in January, an adulterated heart medicine dispensed by the Punjab Institute of Cardiology claimed lives of at least 69 heart patients. It seems appropriate to put these happenings in some perspective.    Cough syrups have been at the center of several cases of mass poisonings around the world in recent years, often involving accidental or intentional use of industrial solvent - diethylene... Read More

How Are Contagious diseases are Transmitted?

Image Overview Infectious diseases are transmitted from person to person by direct or indirect contact. Certain types of viruses, bacteria, parasites, and fungi can all cause infectious disease. Malaria, measles, and respiratory illnesses are examples of infectious diseases.   Simple preventative measures, such as frequent hand washing, can cut down on disease transmission.    Direct contact Infectious diseases are often spread through direct contact. Types of direct contact include:    1. Person-to-person contact Infectious diseases are commonly transmitted through direct person-to-person contact. Transmission occurs when an infected person touches or exchanges body fluids with someone else. This can happen before an... Read More

Fresh access towards the medication of Contagious Diseases

Image The problem of antibiotic resistance in bacteria has reached the crisis stage. Coincident with ever-increasing rates of resistance to conventional antibiotics is the slowing in development of novel-acting antibiotics by the pharmaceutical industry. The convergence of these trends has led to the relatively common occurrence of multidrug- and extensively drug-resistant bacteria. The World Health Organization recently reported that “a postantibiotic era—in which common infections and minor injuries can kill—far from being an apocalyptic fantasy, is instead a very real possibility for the 21st century”. To fathom such a future, one need only ponder the past. At the beginning of the... Read More

Allergen Immunotherapy for Airborne and Food Allergens: Efficacy and Immunological Mechanisms

Image Allergen immunotherapy (AIT) is a disease-modifying treatment for IgE-mediated diseases induced by aeroallergens and food allergens. The efficacy of AIT for airborne allergens is somewhat different from food allergens. The management of allergy induced by aeroallergens involves (i) allergen avoidance; (ii) the use of antihistamines and (iii) nasal corticosteroids. Those who do not respond to pharmacotherapy are than eligible to receive AIT. Long-term administration of AIT results in the modulation of innate and adaptive immune responses and the induction of tolerance. The disease-modifying effect is both antigen-specific and antigen-driven. Clinical improvement is accompanied by decreases in effector cells in target... Read More

Innate Cells in the Pathogenesis of Food Allergy

Image Food allergy is an adverse reaction to dietary antigens that results from a breakdown of immune tolerance to ingested foods. The prevalence of food allergy has risen dramatically in the last few decades. Food allergy has significant morbidity, dramatically impairs quality of life, and creates a tremendous burden on our healthcare system. Although important advances have been made in understanding the breakdown of tolerance and the resultant reactions to food antigens, many aspects of the deviation of the immune response causing food allergy remain unclear. The involvement of IgE and increased T helper 2 (Th2) immune responses in these patients... Read More

NF-kB Pathway Antibodies

Image Author Name: Keith Howell Category Name: Medical science Description: Nuclear Factor kappa-light-chain-enhancer of activated B cells or NF-κB  is found in almost all animal cells and is a protein complex that controls the transcription of DNA. This protein complex is involved in numerous cellular responses and plays a key role in regulating the immune response to infection. NF-κB is also implicated in processes of synaptic plasticity and memory that require additional avenues of research to flesh out completely the possibilities and uses of this compound. All proteins of the NF-κB family share a Rel homology domain in their N-terminus.... Read More

Apoptosis Pathway Antibodies

Image Author Name: Keith Howell Category Name: Medical science Description: In highly organized biological systems like multicellular organisms, tight regulation of growth and death is imminent. If cells are no longer required, they commit suicide by activating an intracellular death program. This method of programmed cell death is called apoptosis (from Ancient Greek ἀπόπτωσις "falling off"). Apoptosis is an energy-dependent biochemical processes characterized by distinct morphological features including cell shrinkage, nuclear fragmentation, chromatin condensation and membrane blebbing. It is a vital component of normal cell turnover, proper development and functioning of the immune system, hormone-dependent atrophy, embryonic development and chemical-induced... Read More

Etiology

Image When a doctor tries to figure out the cause of a disease, they are actually trying to figure out the etiology of the disease. Etiology is the cause of a disease or the science that deals with such causes. The word etiology comes from the Greek etio-, which means 'causation' and -ology, which refers to the scientific study of something. You might be familiar with similar terms such as biology and geology. These words also refer to the scientific study of something. Biology is the study of life (bio) and geology is the study of the earth or rocks (geo). A disease's... Read More

Immune response Towards Covid-19

Image The world experienced the outbreaks of coronavirus infection that threaten global pandemic in 2002-2003 by Severe Acute Respiratory Syndrome (SARS) and in 2011 by Middle East Respiratory Syndrome (MERS). In both cases, the causative agents (SARS-CoV and MERS-CoV, respectively) were newly identified coronavirus in the genus Beta coronavirus with zoonotic origin. At the end of 2019, outbreak of another coronavirus that causes respiratory-related illness was reported in Wuhan, Hubei, China, a disease now officially called “ the Corona Virus Disease 2019; COVID-19”. The coronavirus that is the causative agent of this respiratory disease was identified and its genome is fully... Read More

Unanswered Questions about Covid-19

Image It’s easy to forget that just a few months ago, the virus that is causing the Covid-19 pandemic around the world was not known, at all, to science. In the months and weeks since, researchers have been learning as much as they can about this pathogen — and at breakneck speed. Scientists have sequenced its genome and begun to create vaccines in the hope of making people immune to it. They’ve also learned, critically, that people can pass the virus on to others before they get symptoms themselves. That makes the virus hard to contain. But it also makes it clear that severe actions — like... Read More

IMMULITE ® Technology

Image The heart of IMMULITE 1000 is the proprietary Test Unit, which offers a breakthrough in automated bead washing. The Test Unit, containing an assay-specific coated bead, serves as the reaction vessel for all sample processing. Spinning the Test Unit at high speed efficiently expels fluid into the integral sump chamber. The tube design allows for multiple discrete washes within seconds, ensuring excellent separation of unbound material for highly sensitive assays. IMMULITE 1000's unique wash technique produces extremely low and consistent nonspecific binding, which is critical for assay performance. Sustained Chemiluminescence IMMULITE 1000's enzyme-amplified chemiluminescence translates into lower detection limits... Read More

Breast Cancer in Young Women

Image Breast cancer is the most common malignancy in women worldwide including cancers in young patients (defined as ≤ 40 years). As compared to tumors arising in older patients, breast cancers in young women tend to be diagnosed at more advanced stages and to harbor more aggressive biological features. Young age at breast cancer diagnosis has been historically considered a poor prognostic factor particularly in the case of luminal-like breast cancers. Disparities in tumor biology, inappropriate treatment and lower therapeutic adherence to systemic therapies may be considered potential explanations for these findings. Importantly, when managing young women with newly diagnosed breast... Read More

Nutritional Targeting of Breast Cancer

Image Breast cancer is the leading cancer in women worldwide and is increasing in developing countries where the majority of cases are diagnosed at later stages (WHO, 2018). Mutations in breast cancer genes (i.e. BRCA-1, BRCA-2) confer a high risk of breast cancer. However, familial cases are rare and contribute a relatively small percentage of breast cancer tumors. Risk factors for both familial and sporadic breast cancer include no or delayed reproductive history, exposure to exogenous estrogens, and use of contraceptive or replacement hormones therapies. Dietary and lifestyle-related conditions that affect the risk of breast cancer include overweight and obesity, and... Read More

Tetanus: Case Report, Epidemiology

Image To  describe  a  rare  case  with  generalized  tetanus  to  reinforce  the  relevance  of  early  detection  and management. Case report: A 38 year old Pakistani man presented with neck stiffness to the emergency room 12 d after he had trivial nail injury to his foot for which he didn’t need to seek any medical advice. Tetanus was diagnosed based on clinical symptoms and history. The management consist of antibiotics therapy with penicillin-metronidazole, tetanus toxoid and tetanus immunoglobulin with other supportive measure in the ICU. The patient had full recovery after 6 way in ICU followed by intensive physiotherapy and rehabilitation.... Read More

Various Growth Conditions of Biofilm Associated Extended-Spectrum-Beta-Lactamases Producing Bacteria

Image Extended-Spectrum β-Lactamase (ESBL) producing bacteria are becoming increasingly prevalent in biofilm associated infections. Bacteria form biofilms that allow their survival in hostile environments. The amount of formed biofilm is affected by external environmental factors. This study investigates the effect of specific parameters (media type, incubation condition, and growth stage) on the amount of produced biofilm on antibiotic resistant bacterial strains, Escherichia coli (CTX-M-15, TEM-3, and IMP-type) and Klebsiella pneumoniae (OXA-48, SHV-18, NDM-1, and KPC-3). The amount of biofilm formed was measured at different time points (6, 12, 24 and 48 h) of incubations under static and shaking conditions, using... Read More

Analysis of miR-191-3p in the Spent Blastocyst Culture Media by Droplet Digital PCR

Image Droplet digital PCR analysis of human embryonic culture media collected in a proof of con-cept study  on  IVF  pregnancy  outcome.  miR-191-3p  was  analysed  in  spent  human  embryonic  culture  media  of morphologically similar, good quality embryos which after later transfer developed either to reproductively competent embryos and healthy neonates or of those, where miscarriage occurred in early stage of the pregnancy. Methods: Spent culture media at the morula-blastocyst stage (3rd day) were collected from embryos fertilised with  ICSI  and  undergoing  embryo  transfer.  After  registered  pregnancy  outcome  40  samples  from  the  group  of reproductively competent embryos, 40 samples from miscarriage and their... Read More

Radical Prostatectomy

Image Prostatic adenocarcinoma (PCa) is one of the major contributors to malignancy in men worldwide and second leading cause of cancer death after lung cancer. PCa is an aggressive disease and shows a strong predilection to metastasize into the bones and pelvic lymphatic nodes. In contrast, the metastatic spreads into testicles are rare, accounting up to 4% of all prostate cancer (PCa) cases. Here we present a case from our practice of unilateral testicular metastasis, developed secondary to prostatic carcinoma and diagnosed 6 months after radical prostatectomy. A 69-year-old man presented to our outpatient department for regular follow-up 9 months after... Read More

Human Papillomaviruses and Polyomaviruses in Skin Cancer

Image Nonmelanoma skin cancer (NMSC) is the most common cancer type among Caucasians. The incidence of squamous cell carcinoma is 60-250 times higher in immunosuppressed organ transplant recipients when compared to the general population. An etiologic role of human papillomaviruses (HPV) from genus beta has been suggested for many years because of their well-documented carcinogenicity in patients with epidermodysplasia verruciformis (EV). In addition to the EV patients, their carcinogenic activity has been strengthened in recent years by refined epidemiologic studies and molecular biology, demonstrating oncogenic properties of beta HPV proteins in either keratinocyte cultures or transgenic mice. Viral protein expression has... Read More

Association of polycyclic aromatic hydrocarbons (PAHs) and cancers other than lung cancer

Image There is increasing recognition in the role of polycyclic aromatic hydrocarbons (PAHs) in the etiology of various cancers. Strong mechanistic evidence and carcinogenicity in several animal species has been reported for benzo[a]pyrene, a prototype PAH. Based on this mechanistic evidence and increased risk of lung and skin cancers in several occupations with heavy exposure to PAHs, the International Agency for Research on Cancer has classified benzo[a]pyrene and those occupations as carcinogenic to human. However, although an association between PAHs and some other cancers, e.g. urinary bladder and esophageal cancers, has been suggested, the association between PAHs and cancer in organs... Read More

Rogue cells at root of autoimmune disease

Image Author Name: Keith Howell Category Name: Medical science Description: There are more than 100 different autoimmune diseases. But what unites them all is that they arise from an individual's own cells rare and mysterious immune cells that target not external viruses and bacteria but the body's own healthy organs and tissues. For the first time, Researchers have pinpointed individual cells that cause autoimmune disease from patient samples. They also uncovered how these cells 'go rogue' by evading checkpoints that normally stop immune cells from targeting the body's own tissues. The findings could have significant implications for the diagnosis and treatment of autoimmune... Read More

Timing of immune response to COVID-19 may contribute to disease severity

Image Author Name: Keith Howell Category Name: Medical science Description: A new USC study suggests that temporarily suppressing the body's immune system during the early stages of COVID-19 could help a patient avoid severe symptoms. An interaction between the body's two main lines of defense may be causing the immune system to go into overdrive in some patients. The body's first line of defense, the innate immune response, starts right after an infection, like an infantry going after a foreign invader, killing the virus and any cells damaged by it. The second line of defense, the adaptive immune response, kicks... Read More

Diagnosis ofInvasive Aspergillosis using Galactomannan nd (1-3)-Beta-D-Glucan Assays

Image   Invasive Aspergillosis is an opportunistic mycotic infection witha mortality rate of 15-30% depending on when the infection isdiagnosed and type of therapy elected. While therequirement for a diagnosis of proven invasive pulmonaryaspergillosis remains a lung biopsy for histopathology andculture, these patients are immunocompromised by definitionand such an invasive procedure is often not recommended. Empiric treatment, likewise, is not ideal because the antifungalsrequired to treat invasive aspergillosis are expensive withtreatment of IA in the hospital reaching almost $2900 per dayand antifungals are notoriously toxic. Therefore,diagnosticians increasingly rely on alternative, less invasivetesting. The problem with Aspergillus... Read More

Otomastoiditis- Pneumococcus as Leading Cause, and High Impact of Pneumococcal 13-Valent Conjugate Vaccine

Image   We have published several studies related to Invasive Pneumococcal Disease, and effectiveness of Pneumococcal Conjugate Vaccines: 7-valent (PCV7) and 13-valent (PCV13). This is the first Latin American, prospective study looking for Otomastoiditis (OM) in children, and the impact of PCV13 on this disease. Methods: Since October/1st/2005 until September/30th/2017, prospective surveillance to identify all children<16 years old with OM at the Tijuana, Mexico, General Hospital was performed. OM was diagnosed with otoscopy, and tomographic signs of OM. Bacterial identification was obtained either from mastoids and/or supramastoid abscesses, and bacterial identification by conventional cultures. Pneumococcal serotyping was performed by the... Read More

Clinical Association of Antinuclear Antibodies (ANA) Anti-NuMA1 and Anti-NuMA2 (Anti-HsEg5)

Image The prevalence of anti-NuMA1 and anti-NuMA2 antibodies in autoimmune, hepatic, infectious and renal inflammatory diseases is well known; however, its presence and possible relevance in cardiovascular diseases still needs to be elucidated. Aim: To evaluate the prevalence of positive anti-NuMA1 and anti-NuMA2 antibody patterns in subjects with autoimmune, non-autoimmune and/or cardiac diseases. Material and methods: This was an observational study run from January 2010 to January 2018. Individuals whose treating physician requested an antibody study and we detected anti NuMA1 and anti NuMA2 pattern in any patients. The files from these patients were reviewed to obtain general data, signs, symptoms,... Read More

Study of a Novel Anti-Tubercular Acylhydrazone Schiff Base Derivative

Image Tuberculosis (TB) remains the most serious infectious disease worldwide and predominantly occurs in developing countries. The annual death from TB caused by Multidrug-Resistant (MDR) and Extensively Drug-Resistant (XDR) Mycobacterium Tuberculosis(MTB) outnumbers Human Immunodeficiency Virus (HIV). Especially, 90% of active disease in MDR-TB occurs within the first two years and nearly all within three years, indicating the difficulties of MDR-TB treatment. The traditional anti-TB drugs such asisoniazid, rifampicin, pyrazinamide, ethambutol, streptomycin, kanamycin, amikacin, capreomycin, levofloxacin, ofloxacin have been widely used to treat TB at the doses recommended by the World Health Organization (WHO). However, previous studies suggested that, MDR-TB did not... Read More

Separation of Mixtures of Chiral Compounds by their Distribution between Different Phases

Image The function of living organisms is determined by the behavior of chiral compounds and their reactions. Not only the RNA and DNA influence this function, but the enantiomers of amino acids and sugars also have a dominant role. So, it is not surprising that an increasing number of drugs contain single enantiomers, which are often prepared by resolution of racemic compounds obtained due of chemical syntheses. The therapeutically effect of enantiomers can be different, and it is not rare that these effects are opposite. A tragic reminder of the importance of chirality is thalidomide, in the early 1960s. So, the... Read More

Development of High-performance Thin-layer Chromatography

Image High-Performance Thin Layer Chromatography (HPTLC) is a reliable and rapid method useful for the detection of product quality and composition. In recent times, HPTLC instrumentation allows to obtain fingerprints suitable to determine composition and identity of plant raw materials. This study aimed at exploring the results of High-performance Thin Layer Chromatography (HPTLC) analysis as a useful means for the authentication of Allanblackia parviflora kernel and seed oils using the fingerprint approach. Sixteen bulked kernel and seed oil samples from 16 different communities were analyzed by HPTLC method and their fingerprints were compared. The optimum experimental conditions established were sample mass... Read More

Treatment Development of Chronic Myeloid Leukemia

Image The treatment chosen for your CML largely depends on the phase of your disease, your age and general health. Most people with CML will be treated with drugs called tyrosine kinase inhibitors (TKIs). TKIs work by blocking the activity of an enzyme called bcr-abl and thereby preventing the growth and proliferation of the leukemic cells. The most common decision to be made at diagnosis is which of the three available TKI drugs is most suited to you.  This varies from person to person and your doctor will examine all the information about you that is available to them to decide... Read More

Treatment of Dracunculus Medinensis Infection with Cotrimoxazole

Image Treatment of dracunculiasis in endemic foci may involve either surgery or chemotherapy. Surgical removal of dracunculus is widely practiced in several endemic areas, when the outline of a worm can be seen orpalpated. This approach is however not effective if the worm has burst in the tissue or has broken the skin more than a few days previously. It is also difficult to remove the worm when it is embedded in deep fascia. Over the years, several therapeutic substances have been employed in the treatment of dracunculiasis. Among the earliest trial substances used in West Africa and India were palm... Read More

Malassezia

Image Malassezia yeast exist on all humans and have long been associated with healthy and diseased skin. In this Article Collection of Frontiers in Cellular and Infection Microbiology; Fungal Pathogenesis, we will present multiple papers outlining the state of the art in understanding the role Malassezia in skin health and disease. Over the last thirty years, the term “microbiome” has grown exponentially in scientific discourse, generating hundreds of thousands of publications and patents. Although the human-associated microbial community consists of bacteria, fungi, viruses, and archaea, the vast majority of these publications have been limited to gut bacteria. Only in the two... Read More

Hair Bundles - Development, Maintenance, and Function

Image Inner ear hair cells are characterized by their hairy-looking cell protrusions called hair bundles on the apical cell surface. Hair bundles of each hair cell consist of hundreds of F-actin-based stereocilia and one microtubule-based kinocilium. The stereocilia are organized into several rows of different heights, forming a U-shaped or V-shaped staircase-like pattern. The stereocilium tapers at its base, and a few core actin filaments continue to insert into the F-actin matrix (the cuticular plate) underneath the apical surface. The vertices of U-shaped or V-shaped stereocilia on neighboring hair cells point in a similar direction, establishing the so-called planar cell polarity... Read More

Perceptions, Attitude and Knowledge of Five Moments of Hand Hygiene Practices among Healthcare Workers

Image   The practice of hand hygiene by healthcare workers is critical to preventing Healthcare-associated infections. This study was designed to assess the knowledge, attitude and hand hygiene practices among healthcare workers (HCWs) in Chukwuemeka Odumegwu Ojukwu University Teaching Hospital, Amaku, Awka, Nigeria. A pretested, structured, self-administered questionnaire was used to collect data on the participant’s demographics, their knowledge and attitude to hand hygiene practices. The data collected were analyzed using Statistical Package for Social Sciences (SPSS-20) and presented as frequency and percentages response. Healthcare-associated infection is a significant public health crisis.Healthcare-associated infections (HCAIs) are thought to betransmitted... Read More

Schistosomiasis and Soil Transmitted Helminthiases

Image   With delayed treatment, schistosome and soil transmitted helminth (STH) infections in young children (<5 years)could potentially lead to irreversible lifelong detrimental health effects. This is because these infections are known tocause suboptimal growth and development in this critical phase of life. The present study sought to document theburden of schistosome and STH infections in Taita Taveta County, Kenya, by determining the prevalence andintensity of the infections in children less than 5 years of age. The study also appraised the association betweeninfections with schistosomes, anaemia and nutritional status in children. A total of 132 children, 53.8% males, wereenrolled... Read More

Improving Laboratory Turnaround Time in a High Throughput Medical Laboratory

Image   One measure of efficiency in a diagnostic laboratory is promptness in producing results. With this in mind, turnaround time (TAT) has become a conspicuous indicator reflecting a lab’s efficiency. Delays in TAT in a high throughput laboratory such as Quantum Diagnostics were identified. Urgent and non-urgent tests TAT which includes H. pylori and EBV tests alongside routine biochemistry were collected from July 2017 till January 2019. Prior to August 2017, samples were run for biochemistry tests on Cobas 8000 (Roche Diagnostics, Germany) prior to processing serology H. pylori (Immulite 2000, Siemens) and EBV (Snibe, BMS) tests. Delayed TAT was... Read More

Cross-Reactivity Measurement of Cashew Nut, Hazelnut and Peanuts

Image   Tree nut allergic individuals are often sensitised towards multiple nuts and seeds. The underlying cause behind a multi-sensitisation for cashew nut, hazelnut, peanut and birch pollen is not always clear. We investigated whether IgE cross-reactivity between cashew nut-, hazelnut- and peanut proteins exists in children that are multi-allergic to these foods using a novel IMMULITE®-based inhibition methodology, and investigated which allergens might be responsible. In addition, we explored if an allergy to birch pollen might play a role in this cosensitisation for cashew nut, hazelnut and peanut. Serum of five children with a confirmed cashew nut allergy and suffering... Read More

Human Sport Doping Control Analysis is a Complex and Challenging Task for Anti-Doping Laboratories

Image Human doping refers to the use of performance-enhancing drugs by the athletes. Human sport doping control analysis is a complex and challenging task for anti-doping laboratories. The field is regulated by the World Anti-Doping Agency (WADA), whose aim is to achieve globally harmonized results and equal treatment for all athletes. The List of Prohibited Substances and Methods is updated annually by WADA and consists of hundreds of chemically and pharmacologically different low and high molecular weight (MW) compounds. In sports, today the aim is to provide equal opportunities for athletes to seek victory and fame. Hence, the use of performance-enhancing... Read More

The role of a statistician in drug development: Pre-Clinical Drug Development

Image Before a novel compound is evaluated in human trials, preliminary characterization of the toxicology profile as well as the efficacy and drug metabolism should be assessed in pre-clinical studies. This can be performed using basic techniques or more advanced strategies such as pharmacokinetic-pharmacodynamic (PK-PD) modelling. The findings may be used to predict how humans would react to the drug, as the disease progression and the PK-PD relationship in humans could be consistent, to some extent, with animal study results. Furthermore, data accumulated from animal experiments that have been well designed, conducted and analysed will contribute to a more successful translation... Read More

Melanoma genetics/genomics

Image Melanoma is a complex disease driven both by genetic and environmental risk factors, and requires multiple genetic mutations in the evolution from benign nevus into malignant melanoma (MM). Genetic studies of familial and sporadic melanoma have revealed surprising insights into the molecular pathogenesis of this deadly cancer. Collectively, the molecular data show there are four signature pathways involved in melanomagenesis: activation of the RAS?RAF?MEK?ERK and PI3K?AKT pathways and inactivation of the INK4a?RB and ARF?P53 pathways (Chin, 2003). Acting in a coordinated manner, these pathways provide melanocytes the requisite acquired abilities needed to develop into cancer cells: growth-factor independence, insensitivity to... Read More

Mast Cells in Itch, Pain and Neuro-inflammation

Image Mast cells are ubiquitously present in most tissues, especially surfaces exposed to the environment, close to blood vessels and nerve fibers, as well as in the meninges and the hypothalamus. Mast cells serve as environmental ‘sensors’ and communicate with hormonal, immune and neural systems leading to immune and inflammatory responses. Mast cells serve as first responders with an inherent ability to rapidly release a plethora of mediators, often selectively, depending on exogenous, or endogenous stimuli. In addition to the classical IgE-dependent mode of stimulation, mast cells react to a multitude of other stimuli, including cytokines, hormones, neuropeptides and neurotransmitters. Different... Read More

Rapid Optical Detection Strategy for Human Pathogens

Image Quick, sensitive and specific detection of infectious agents can aid in better treatment of patients and forrecognition of contaminants. Traditional methods suffer from drawbacks of being time consuming and tedious toperform and modern medicine advances call for better detection methods. Strategies employing nanoparticle basedsystems are under investigation to allow for efficient and rapid detection of pathogenic microorganisms.Nanoparticles have been conjugated with nucleic acid probes and antibodies to serve as one step detection system,based on conserved genomic DNA sequences and specific surface proteins expressed by the microorganisms,respectively. Unique size based colorimetric properties are being exploited for developing optical sensors enablingresult visualization... Read More

Overview of Clostridium difficile Infection in Cancer Patients

Image Clostridium difficile Associated Diarrhoea (CDAD) is the leading cause of nosocomial diarrhoea. Clostridium difficile Infections (CDIs) may be induced by medication or medical procedures that disrupt normal bowel flora or interfere with bowel motility. The emergence of hyper-virulent strains of CDI, reports of severe or recurrent CDI in immune competent populations, advent of various infection control challenges, and diagnostic and therapeutic dilemmas have contributed to a shift in the disease paradigm. However, there is insufficient data on the risk of CDI in vulnerable cancer patients receiving chemotherapy or who are admitted to health care settings for long periods of time.... Read More

What are the stages of drug development process?

Image The process of bringing a medicine to the market takes up to 12 years, from initial discovery in the laboratory, through the phases of clinical testing to being licensed and available on the market. Once a molecule is discovered, it undergoes extensive laboratory testing and experiments with animals in order to show its potential properties, safety and its value as a new therapy. The results from the pre-clinical phase are then submitted to regulatory authorities for approval to be tested on people in clinical trials. The clinical trials stage consists of three main phases and all new medicines have to... Read More

Application of Cancer Antigen 125 Test in Diagnosis of Pulmonary Tuberculosis

Image Pulmonary tuberculosis (TB) is a contagious bacterial infection that attacks the lungs and spread to other organs. Globally, tuberculosis remains one of the leading causes of death and public health problems despite dramatic improvements made in providing access to high-quality TB services. WHO estimates that about one third of all incident cases of active TB are not properly diagnosed or receive care of poor quality outside of national TB programs. Among diagnosed cases, the delay of the result is often long. Determination of disease activity of pulmonary tuberculosis is important for treatment; but follow-up of the infection activity... Read More

Why Preventing Cancer Is Not the Priority in Drug Development

Image The way the patent system interacts with the Food and Drug Administration’s drug approval process skews what kinds of cancer clinical trials are run. There’s more money to be made investing in drugs that will extend cancer patients’ lives by a few months than in drugs that would prevent cancer in the first place. “R & D on cancer prevention and treatment of early-stage cancer is very socially valuable,” the authors told me in an email, “yet our work shows that society provides private firms — perhaps inadvertently — with surprisingly few incentives to conduct this kind of research.” To... Read More

Need for Reference Ranges

Image Reference data for clinical chemistry on reference values of children in Taita Taveta County are fundamental for clinical diagnosis, management and research. In such a study, a target sample population of 120 respondents is usually required. In this study, a total of 577 healthy subjects from Taita Taveta population were employed to generate the normal reference data on eight clinical chemistry markers. The data obtained will provide needed information to medical practitioners with regards to patient management, as well as conducting research studies on disease. The normal laboratory reference values currently employed in clinical and research institution in... Read More

Single-molecule nanomechanical mass spectrometry

Image Nanoelectromechanical systems (NEMS) are enabling important emerging applications in diverse fields ranging from quantum measurement to biotechnology. In general, the smaller a device, the more susceptible are its physical properties to perturbation by external influences. This enhanced sensitivity of NEMS is opening a variety of unprecedented opportunities for applications such as mass spectrometry, which is now widely used for proteomics. Furthermore, to reliably detect the expression of low-level signals and to understand the fundamental biological processes, it is important to develop techniques capable of single cell or single-molecule analyses. In this work, the exceptional mass sensitivity of ultrahigh-frequency (UHF) NEMS... Read More

New and Emerging Analytical Techniques for the Detection of Organic Contaminants in Water

Image Detailed chemical analysis of water is a prerequisite for assuring the safety of water supplies. Limitations in our ability to identify contaminants in water also limit our ability to assure water quality and to assess environmental impacts. Recent improvements in analytical techniques have expanded the "analytical window," that is, the compound range that is amenable to specific identification. Using these improved tools, much has been learned about the occurrence, fate, and transport of organic chemicals in the environment. The boundaries of the analytical window represent the "analytical frontiers" and are continuously expanded. These boundaries are defined loosely by the contaminant... Read More

How Do Cells Recognize Signals?

Image Author Name: Keith Howell Category Name: Medical science Description: Most cell signals are chemical in nature. For example, prokaryotic organisms have sensors that detect nutrients and help them navigate toward food sources. In multicellular organisms, growth factors, hormones, neurotransmitters, and extracellular matrix components are some of the many types of chemical signals cells use. These substances can exert their effects locally, or they might travel over long distances. For instance, neurotransmitters are a class of short-range signaling molecules that travel across the tiny spaces between adjacent neurons or between neurons and muscle cells. Other signaling molecules must move much farther to... Read More

CRISPR corrects genetic defect so cells can normalize blood sugar

Image Author Name: Keith Howell Category Name: Medical science Description: The findings, from researchers suggest the CRISPR-Cas9 technique may hold promise as a treatment for diabetes, particularly the forms caused by a single gene mutation, and it also may be useful one day in some patients with the more common forms of diabetes, such as type 1 and type 2. Patients with Wolfram syndrome develop diabetes during childhood or adolescence and quickly require insulin-replacement therapy, requiring insulin injections multiple times each day. Most go on to develop problems with vision and balance, as well as other issues, and in many... Read More

Melanoma and Other Skin Cancers

Image New therapies are currently being developed in the field of skin cancer. In particular, advances in melanoma now represent the frontline of cancer immunotherapy, as immunological findings in the disease have led to the development of highly effective immune-checkpoint inhibitors. However, these immune-checkpoint inhibitors are only effective in a subset of patients, and may not work in other skin cancer types, thus highlighting the need for further innovation in the field of skin cancer treatment. The purpose of this Research Topic is therefore to provide an up-to-date overview of immune processes and new therapies for melanoma and other skin cancers... Read More

New Therapies and Immunological Findings in Melanoma

Image New therapies are currently being developed in the field of skin cancer. In particular, advances in melanoma now represent the frontline of cancer immunotherapy, as immunological findings in the disease have led to the development of highly effective immune-checkpoint inhibitors. However, these immune-checkpoint inhibitors are only effective in a subset of patients, and may not work in other skin cancer types, thus highlighting the need for further innovation in the field of skin cancer treatment. The purpose of this Research Topic is therefore to provide an up-to-date overview of immune processes and new therapies for melanoma and other skin cancers... Read More

Paediatric Giardiasis

Image   Giardiasis, an illness that affects the digestive tract (stomach and intestines), is caused by a microscopic parasite called Giardia lamblia. The parasite attaches itself to the lining of the small intestines in humans, where it interferes with the body's absorption of fats and carbohydrates from digested foods. Giardia is one of the chief causes of diarrhea in the United States, and spreads through contaminated water. It can survive the normal amounts of chlorine used to purify community water supplies, and can live for more than 2 months in cold water. As few as 10 of the microscopic... Read More

Neuropathogenic Coronaviral Infection

Image   Murine coronavirus, mouse hepatitis virus (MHV), causes various diseases depending on the strain and route of inoculation. Both the JHM and A59 strains, when inoculated intracranially or intranasally, are neurovirulent. Comparison of the highly virulent JHM isolate, JHM.SD, with less virulent JHM isolates and with A59 has been used to determine the mechanisms and genes responsible for high neuropathogenicity of MHV. The focus of this review is on the contributions of viral spread, replication, and innate and adaptive immunity to MHV neuropathogenesis. JHM.SD spreads more quickly among neurons than less neurovirulent MHVs, and is able to... Read More

Kind of Signals Do Cells Receive

Image Author Name: Keith Howell Category Name: Medical science Description: Most cell signals are chemical in nature. For example, prokaryotic organisms have sensors that detect nutrients and help them navigate toward food sources. In multicellular organisms, growth factors, hormones, neurotransmitters, and extracellular matrix components are some of the many types of chemical signals cells use. These substances can exert their effects locally, or they might travel over long distances. For instance, neurotransmitters are a class of short-range signaling molecules that travel across the tiny spaces between adjacent neurons or between neurons and muscle cells. Other signaling molecules must move much farther to... Read More

biological systems using lipidomics

Image The mass spectrometry (MS) resources on campus aim to provide researchers with state-of-the-art techniques and equipment to characterize biomolecules including proteins and peptides (proteomics, sugars including glycoproteins (glycemic), metabolites (metabolomics) and lipids (lipidomics). A number of state-of-the-art instruments for the separation of biomolecules and their analysis by mass spectrometry-based approaches are available. In addition to providing analytical services, the mass spectrometry facility on campus provides training to on-campus scientific staff on the use of this technology as well as develop new analytical methods required to facilitate on campus research. Lipidomics Facility is driven to establish a hyphenated Mass Spectrometry based... Read More

Cell Signaling: Architectural Beauty and Complexity

Image Author Name: Keith Howell Category Name: Medical science Description: A clear theme that emerges is the enormous complexity that underlies most cellular responses and the vast variety of proteins and interaction/binding motifs used to transduce signals. The extent of complexity is particularly surprising when one considers that as recently as the late 80s and early 90s many believed that all cellular signaling pathways consisted of a relatively simple sequence of protein–protein interactions. The discovery that heterotrimeric GTP binding proteins (G proteins) act as molecular switches, linking the activation of seven-membrane spanning receptors (also known as hepathelical or serpentine receptors)... Read More

Psoriasis

Image   Psoriasis is a common skin condition that speeds up the life cycle of skin cells. It causes cells to build up rapidly on the surface of the skin. The extra skin cells form scales and red patches that are itchy and sometimes painful. Psoriasis is a chronic disease that often comes and goes. The main goal of treatment is to stop the skin cells from growing so quickly. There is no cure for psoriasis, but you can manage symptoms. Lifestyle measures, such as moisturizing, quitting smoking and managing stress, may help. Symptoms Psoriasis signs and symptoms are different for... Read More

Electrokinetic Treatment Technique for Improving the Engineering Characteristics of Low Permeable Problematic Soils

Image In recent years, major settling or tilting of buildings and bridges, instability of dams and road embankments have been observed and many attempts have been made in order to mitigate such damages. In this regard, it is necessary to determine the soil improvement alternatives, technically and economically, from the ultimate state design in accordance with geotechnical categories, to stabilize and remediate the existing soft problematic soils prior to the commencement of any construction activities. The aims of improving soils (as foundation and construction materials) are to increase strength, reduce distortion under stress, reduce compressibility, control shrinking and swelling, control permeability... Read More

Acute Myocardial Infraction

Image   What is acute myocardial infarction? Acute myocardial infarction is the medical name for a heart attack. A heart attack is a life-threatening condition that occurs when blood flow to the heart muscle is abruptly cut off, causing tissue damage. This is usually the result of a blockage in one or more of the coronary arteries. A blockage can develop due to a buildup of plaque, a substance mostly made of fat, cholesterol, and cellular waste products. What are the symptoms of acute myocardial infarction? While the classic symptoms of a heart attack are chest pain and shortness... Read More

COVID-19: Prevention & Investigational Treatments

Image COVID-19 is the disease caused by an infection of the SARS-CoV-2 virus, first identified in the city of Wuhan, in China's Hubei province in December 2019. COVID-19 was previously known as 2019 Novel Coronavirus (2019-nCoV) respiratory disease before the World Health Organization (WHO) declared the official name as COVID-19 in February 2020. Symptoms The most common symptoms of COVID-19 include dry cough, fever, and shortness of breath. It is thought that symptoms can appear between 2-14 days after exposure although there have been isolated cases which suggest this may be longer. If you develop symptoms, you should stay at home... Read More

Hydroxychloroquine, chloroquine and other potential COVID-19 treatments

Image During two of this week’s White House briefings, President Trump referred specifically to two potential treatments that have been identified by medical researchers and clinicians, and that have undergone various degrees of investigation and testing in the ongoing fight against the global coronavirus pandemic. It’s important to note upfront that regardless of what you may have heard, from Trump or any other sources, no drugs or treatments have been proven as effective for either the prevention of contracting COVID-19 or for its treatment. That said, a number of different clinical studies are currently in progress all over the world, and... Read More

Smart Strategies to Reuse Natural Materials as Drug Delivery Platforms

Image Recently, macromolecules obtained from biomasses, residues or by-products of industrial processes have attracted the interest of the scientific community as valid and green alternatives to polymers of fossil origins. In fact, the substitution of synthetic materials with naturally-derived systems represents an extremely urgent target to effectively achieve sustainable production strategies, within the UN Sustainable Development Goals frame. In this context, food, textile and paper industries may be considered as sources of renewable resources for bio-based material production. Distinctive features of natural processes are their ability to dynamically self-organize and self-heal, leading to complex 3D structures which transcend the scalability concept.... Read More

Nicotinic Alpha9 and Alpha10 Subunits: Ancient Receptors in Modern Times and Modern Places

Image Nicotinic acetylcholine receptors (nAChRs) are ion-gated channels that have diverse function in nervous and non-nervous tissues. The α9 and α10 subunits are members of the subfamily I, epithelial ion-gated nicotinic receptor gene family. These subunits are the most recently discovered (and perhaps the last to be discovered) nAChR subunits in mammals, but are phylogenetically the oldest. The α9 and α10 subunits are not expressed in the mammalian brain, making them unique among nAChRs. They were first localized in cochlear hair cells. As a consequence of their discovery in hair cells, the focus of study of these subunits has largely been... Read More

CVDs

Image Cardiovascular diseases (CVDs) are a group of disorders of the heart and blood vessels and they include: coronary heart disease – disease of the blood vessels supplying the heart muscle; cerebrovascular disease – disease of the blood vessels supplying the brain; peripheral arterial disease – disease of blood vessels supplying the arms and legs; rheumatic heart disease – damage to the heart muscle and heart valves from rheumatic fever, caused by streptococcal bacteria; congenital heart disease – malformations of heart structure existing at birth; deep vein thrombosis and pulmonary embolism – blood clots in the leg veins, which can... Read More

Parasitic Infections

Image Parasites are organisms that live in (or on) another organism, called the host. The parasites can be microscopic or large enough to see with the naked eye, and they survive by feeding from the host. They can also spread parasitic infections, which can lead to sepsis. Sometimes incorrectly called blood poisoning, sepsis is the body’s often deadly response to infection. Sepsis kills and disables millions and requires early suspicion and rapid treatment for survival. Sepsis is and septic shock can result from an infection anywhere in the body, such as pneumonia, influenza, or ... Read More

Hepatitis-B

Image Hepatitis B is a potentially life-threatening liver infection caused by the hepatitis B virus (HBV). It is a major global health problem. It can cause chronic infection and puts people at high risk of death from cirrhosis and liver cancer. A safe and effective vaccine that offers a 98-100% protection against hepatitis B is available. Preventing hepatitis B infection averts the development of complications including the development of chronic disease and liver cancer. Transmission In highly endemic areas, hepatitis B is most commonly spread from mother to child at birth (perinatal transmission), or through horizontal transmission (exposure to infected blood),... Read More

Testicular Metastases

Image Metastases to testis are a very rare cause of a testicular mass and may be bilateral in up to 15% of patients.  Epidemiology Metastases to the testes are apparent in ~0.04% of autopsy studies in patients with known malignancy. The average age is 57 years, much older than the primary age for primary testicular cancer.  Pathology The literature suggests that the rarity of metastases to the testes may be due to: lower temperature of the scrotum, so the malignant cells find it more difficult to proliferate testes are a 'sanctuary' site - due to the blood-testicular barrier... Read More

Old human cells rejuvenated with stem cell technology

Image Author Name: Keith Howell Category Name: Medical science Description: Old human cells return to a more youthful and vigorous state after being induced to briefly express a panel of proteins involved in embryonic development. The researchers also found that elderly mice regained youthful strength after their existing muscle stem cells were subjected to the rejuvenating protein treatment and transplanted back into their bodies. The proteins, known as Yamanaka factors, are commonly used to transform an adult cell into what are known as induced pluripotent stem cells, or iPS cells. Induced pluripotent stem cells can become nearly any type of... Read More

COVID-19 coronavirus epidemic has a natural origin

Image Author Name: Keith Howell Category Name: Medical science Description: The analysis of public genome sequence data from SARS-CoV-2 and related viruses found no evidence that the virus was made in a laboratory or otherwise engineered. By comparing the available genome sequence data for known coronavirus strains, we can firmly determine that SARS-CoV-2 originated through natural processes In addition to researcher"The proximal origin of SARS-CoV-2," Coronaviruses are a large family of viruses that can cause illnesses ranging widely in severity. The first known severe illness caused by a coronavirus emerged with the 2003 Severe Acute Respiratory Syndrome (SARS) epidemic in... Read More

Recent Developments in Therapies and Diagnostic Tools for Melanoma and Non-melanoma Skin Cancer

Image This research comprises three sections: 1) recent therapeutic options for advanced melanoma and non-melanoma skin cancers; 2) investigation of biomarkers to predict the efficacy and adverse events (AEs) for melanoma and non-melanoma patients; and 3) novel diagnostic tools for skin cancers. The last 5 years have seen a great paradigm shift in the treatment of skin cancers, particularly for advanced melanoma. Indeed, once immune checkpoint inhibitors and BRAF inhibitors became available, therapeutic strategies for the treatment of advanced melanoma have changed markedly, prolonging survival and even improving quality of life for patients. Subsequent to these successes in the treatment of... Read More

Melatonin in Health and Disease

Image While some hormones are “trophic” in terms of their target tissues being primarily other endocrine cells (e.g. TSH, ACTH, gonadotrophins, etc.), most hormones are “pleiotropic” in as much as their target tissues are numerous and functionally heterogeneous. Thyroid hormones, insulin, adrenocorticoids and sex steroids are among the most obvious examples of this. The hormone of the brain’s pineal gland, melatonin (5-methoxy-N-acetyltryptamine) is another notable member of this class, with some interesting parallels to the other hormones mentioned. For example, like steroids and thyroxine, melatonin is secreted without exocytosis and crosses target cell membranes. Melatonin is an evolutionary old molecule that... Read More

Identification of new bioactive compounds; hyphenated techniques

Image The second objective of this research line is the identification, characterization and study of the biological activity of diverse natural sources of bioactive compounds with potential application in the treatment or prevention of obesity and its associated comorbidities. These bioactive compounds are of great interest for both the food and the pharmaceutical industry, as they can be the basis for the development of new dietary supplements or functional foods. To this end, activity studies of new extracts or molecules are developed in various models (in vitro, C. elegans, rat / mouse, etc.) in order to select candidates prior to their... Read More

Monoclonal antibodies in multiple myeloma therapy

Image Multiple myeloma (MM) results from the proliferation of a malignant plasma cell and frequently leads to complications such as lytic bone disease, hypercalcemia, renal failure, and impaired immunity. Over the past 2 decades, progression-free survival (PFS) and overall survival for MM have more than doubled, largely due to improvements in therapy with the addition of novel agents such as immunomodulatory agents (IMiDs) and proteasome inhibitors (PIs).  The understanding of MM pathobiology has undergone a similar period of growth, leading to the discovery of novel targets and pathways that impact proliferation and survival of the malignant clone. Despite these significant improvements, MM... Read More

Pharma Unlike FDA, European regulators refuse to clear chloroquine for COVID-19 without data

Image Chloroquine and hydroxychloroquine have drawn more attention—and certainly more presidential support—than any other drug during the global quest to find an effective coronavirus therapy. Now, days after the FDA gave them an emergency approval to treat COVID-19, European regulators are limiting their COVID-19 use to clinical trials only. The decision comes as limited data—some of it questionable—rolls in about the drugs and their potential as COVID-19 therapies. A French study that's made headlines continues to draw fire, but brand-new data from China add to the positive case. In guidance Wednesday, the European Medicines Agency restricted general use of the drugs—already approved to treat malaria and autoimmune... Read More

COVID-19 is bad news for new drug launches. Which will suffer most?

Image The COVID-19 pandemic and the ensuing societal countermeasures are upending operations in many sectors—and biopharma isn't immune. The current lockdown is not only hurting clinical trial enrollment but also delaying regulatory timelines for drugs nearing a decision. And with tried-and-true, in-person marketing techniques no longer allowed, new launches may also feel the pain—or hold off altogether. Consider Bristol Myers Squibb and its big new approval for multiple sclerosis drug Zeposia. It's a long-awaited med, but BMS is postponing the launch under the circumstances.  Also in the MS arena, a regulatory decision for Novartis’ repurposed ofatumumab might also come late, ODDO... Read More

Disorders of Follicular Occlusion: Exploring Pathogenic Mechanisms to Identify Novel Therapeutic Targets

Image Disorders of Follicular Occlusion include the conditions Hidradenitis Suppurativa (HS), Dissecting Cellulitis of the Scalp (DCS), Acne Congolobata (AC) and Pilonidal Sinus Disease (PD). All of these disorders are chronic, burdensome diseases with few efficacious therapeutic options. The prevailing pathogenic paradigm in these disorders are follicular occlusion via a variety of endogenous and exogenous mechanisms, resulting in follicular rupture and dermal inflammatory response. The term ‘disorders of follicular occlusion’ was first coined in 1956 by Pillsbury, Shelley and Kligman based upon commonalities in histopathological and clinical manifestations. However, since this time our understanding of follicular biology, physiology and cutaneous immunology... Read More

Sarcoidosis

Image Sarcoidosis is a granulomatous disease of unclear etiology with the potential affection of major organs. It most commonly affects the lungs, skin, eyes, and lymph nodes. Less frequent, though possibly underestimated, manifestations are rheumatic and renal disease. As a systemic disease, it can present in numerous ways and mimic many other conditions, including infections and cancer. While it has been proposed that an abnormal immunologic response to antigens leads to granulomatous inflammation in genetically predisposed individuals, much has to be learned. Sarcoidosis can present as an acute and self-limiting disease or progress to a chronic and potentially debilitating disorder. The... Read More

Cell Signaling :CRISPR gene cuts may offer new way to chart human genome

Image Author Name: Keith Howell Category Name: Medical science Description: The researchers say that pairing CRISPR with tools that sequence the DNA components of human cancer tissue is a technique that could, one day, enable fast, relatively cheap sequencing of patients' tumors, streamlining the selection and use of treatments that target highly specific and personal genetic alterations.For tumor sequencing in cancer patients, you don't necessarily need to sequence the whole cancer genome, says researcher. "Deep sequencing of particular areas of genetic interest can be very informative." In conventional genome sequencing, scientists have to make many copies of the DNA at... Read More

New Drugs Approval

Image   1) Zeposia (ozanimod) Capsules  Company: Bristol-Myers Squibb Company  Date of Approval: March 25, 2020  Treatment for: Multiple Sclerosis  Zeposia (ozanimod) is a sphingosine 1-phosphate receptor modulator indicated for the treatment of relapsing forms of multiple sclerosis (MS).  2) Isturisa (osilodrostat) Tablets  Company: Novartis Pharmaceuticals Corporation  Date of Approval: March 6, 2020  Treatment for: Cushing's Syndrome    Isturisa (osilodrostat) is a cortisol synthesis inhibitor indicated for the treatment of adult patients with Cushing’s disease.  3) Durysta (bimatoprost) Implant  ... Read More

The Importance of Medicines

Image There has been a spate of drug related illnesses and deaths reported from Pakistan in the press this year. In November, at least 17 people died in the eastern city of Lahore after drinking toxic cough syrup. Earlier in January, an adulterated heart medicine dispensed by the Punjab Institute of Cardiology claimed lives of at least 69 heart patients. It seems appropriate to put these happenings in some perspective.   Cough syrups have been at the center of several cases of mass poisonings around the world in recent years, often involving accidental or intentional use of... Read More

How Are Diseases Transmitted?

Image Overview  Infectious diseases are transmitted from person to person by direct or indirect contact. Certain types of viruses, bacteria, parasites, and fungi can all cause infectious disease. Malaria, measles, and respiratory illnesses are examples of infectious diseases.  Simple preventative measures, such as frequent hand washing, can cut down on disease transmission.   Direct contact  Infectious diseases are often spread through direct contact. Types of direct contact include:   1. Person-to-person contact  Infectious diseases are commonly transmitted through direct person-to-person contact. Transmission occurs when an infected person... Read More

Cell receptors are generally transmembrane proteins

Image Author Name: Keith Howell Category Name: Medical science Description:  Cells have proteins called receptors that bind to signaling molecules and initiate a physiological response. Different receptors are specific for different molecules. Dopamine receptors bind dopamine, insulin receptors bind insulin, nerve growth factor receptors bind nerve growth factor, and so on. In fact, there are hundreds of receptor types found in cells, and varying cell types have different populations of receptors. Receptors can also respond directly to light or pressure, which makes cells sensitive to events in the atmosphere. Receptors are generally transmembrane proteins, which bind to signaling molecules... Read More

New approaches for treatment of Infectious Diseases

Image The problem of antibiotic resistance in bacteria has reached the crisis stage. Coincident with ever-increasing rates of resistance to conventional antibiotics is the slowing in development of novel-acting antibiotics by the pharmaceutical industry. The convergence of these trends has led to the relatively common occurrence of multidrug- and extensively drug-resistant bacteria. The World Health Organization recently reported that “a postantibiotic era—in which common infections and minor injuries can kill—far from being an apocalyptic fantasy, is instead a very real possibility for the 21st century”. To fathom such a future, one need only ponder the past. At the beginning... Read More

Chromatography is the most widely used separation technique in chemical laboratories

Image Chromatography is the most widely used separation technique in chemical laboratories, where it is used in analysis, isolation and purification, and it is commonly used in the chemical process industry as a component of small and large-scale production. In terms of scale, at one extreme minute quantities of less than a nanogram are separated and identified during analysis, while at the other, hundreds of kilograms of material per hour are processed into refined products. It is the versatility of chromatography in its many variants that is behind its ubiquitous status in separation science, coupled with simplicity of approach and a... Read More

Drug Absorption

Image Absorption is the transfer of the drug into the bloodstream. In IV this process is complete thus the whole dose reaches the systemic circulation. However in other routes of administration the rate and efficiency is dependent on many factors and usually on ly results in partial absorption. Transport in GIT Due to their chemical properties, drugs are absorbed either by passive diffusion or active transport. Passive diffusion: Passive diffusion is facilitated by the concentration gradient accross the membrane. The drug moves from high concentration to low concentration, it does not require an extra carrier or extra energy. Water-soluble agents use... Read More

Probiotics in clinical practice

Image The interaction of the gastrointestinal microflora with the human host has been the subject of considerable debate in the last decade. Manipulation of the enteric microflora with probiotic organisms has been attempted in a wide range of clinical settings, in the hope of achieving health benefits in the host. This review presents the evidence from human clinical trials of probiotics in the areas of diarrhoeal illness, inflammatory bowel disease, surgical prophylaxis, critical care and serum lipid modulation. With the exception of childhood viral diarrhoea, there is little evidence... Read More

Probiotic activities of Lactobacillus casei rhamnosus

Image The interest of probiotics as remedies for a broad number of gastrointestinal and other infectious diseases has gained wide interest over the last few years, but little is known about their underlying mechanism of action. The inhibitory effects of Lcr35 organisms on the adherence of three pathogens, enteropathogenic Escherichia coli (EPEC), enterotoxigenic E. coli (ETEC) and Klebsiella pneumoniae, were determined. A decrease in the number of adhering pathogens was observed, using either preincubation, postincubation or coincubation of the pathogens with Lcr35. Moreover, the antibacterial activities of cell-free Lcr35 supernatant was examined against nine human... Read More

Drug Analysis

Image What is Drugs Analysis? Within forensic science the role of the drugs section is to prove to a satisfactory level to the court, including the defence, what a substance is and ascertain whether or not it contains any drugs controlled under current legislation. To do this to the level required by the court involves performing a chemical analysis.  As well as determining exactly what drug may be in a given substance (qualitative analysis), further chemical analysis can determine the amount of the drug present and thereby provide the purity of the substance (quantitative analysis). How We Analyse Drugs There are... Read More

Mineral Nutrient Sensing and Signaling

Image Macronutrients such as nitrogen, phosphate, sulphate and micronutrients such as iron, copper and zinc are essential for various aspects of plant growth and development, but these elements may also be toxic if accumulated in the plant cell in excess. Non-essential elements like cadmium, arsenic, and aluminum are potentially highly toxic; however they are increasingly being emitted into the environment due to anthropogenic activities. Soils often challenge sessile plants with poor availability of essential minerals or elevated concentrations of toxic elements. These challenges are often exacerbated by soil type. For example, NO3− is the main source of inorganic nitrogen for plants... Read More

Hormone Receptors and Breast Cancer

Image Breast cancer is the most commonly diagnosed cancer in women worldwide and is the second leading cause of cancer-related deaths. The vast majority of breast cancers arise from epithelial cells, either in the ducts or lobules, as a consequence of genetic and epigenetic alterations, which lead to aberrant growth control and disruption of intracellular signalling at the tissue level. For these reasons, breast cancer is a heterogeneous disease with multiple sub-types, with distinct cells of origin and etiology. The increased expression of estrogen receptors (ER), that occurs at the earlier stages of breast tumor development and is common to different... Read More

Biosensor H2O2 by Using Immobilized Horseradish Peroxidase Glutaraldehyde

Image An enzymatic biosensor has been developed for detection of hydrogen peroxide with immobilized Horseradish peroxidase (HRP). HRP was immobilized by using glutaraldehyde (GA) that cross linked with modified polyaniline (PANI) as mediator to improve electron transfer. Modified carbon paste electrodes (MCPE) PANI was more effective during electron transfer compared to carbon paste electrodes (CPE). Cyclic voltammetry method (VC) was used to determine the electrochemical properties of the modified electrode substrate to produce redox reactions. The effect of pH and temperature were analysed by cyclic voltammetry. The optimum performance of HRP/GA/PANI was at pH 7 and 50°C. Kinetics parameters HRP enzyme... Read More

Enzyme Enabled Antibiotic Production

Image Manufacturing is the life line and driver of economic development; by producing goods we not only achieve growth but also vastly improve our quality of life. Manufacturing in simple terms means taking certain raw materials and converting them into value added products and invariably nuisance value by-products or creating eco-impact at various levels and with more. In addition, consumption of the key material from the nature depletes the same and without a concerted eco-responsible effort the natural resource is lost for ever. Green Manufacturing Enabling Sustainability A paradigm shift in manufacturing mind-set, defined figuratively as “Green manufacturing” has emerged as... Read More

N-Acetyl Cysteine Decreases Mice Brain Acetyl Cholinesterase Activity

Image Here a kinetic in vitro study of n-acetylcysteine (NAC) on mouse brain acetylcholinesterase (AChE) activity was performed, as well, few studies with the aim to improve Ellman’s methodology based on SH contain compounds. The ideal 5,5´-dithio-bis-2-nitrobenzoic acid (DTNB) concentration was of 0.3 mM and ideal medium pH=7.4. AChE demonstrated linear activity for all acetylthiocholine iodide (ATCh) tested concentrations (0.025-0.450 mM). To avoid any DTNB-NAC interaction interference, 30 sec were applied to the assay method, so-called stabilization time. No differences in Km (mM) for all NAC tested concentrations were observed. At the NAC concentrations started from 75 µM significant differences in... Read More

Lipase Catalysed Trans Esterification

Image   There has been great emphasis on the use of biodiesel due to worldwide scarcity of fossil fuels, increasing crude oil prices and environmental concerns to reduce pollution. Production of biodiesel from biologically derived oils involves trans esterification of these triglycerides with short chain alcohols to yield alkyl esters of fatty acids. These can be used in engines which are having compression ignition (diesel) and are termed as “biodiesel”. Trans esterification catalysis reaction can be chemical and enzymatic by nature. The disadvantages of chemical synthesis processes (for instance expenditure of high energy, triglycerides trans esterification with high free fatty acid... Read More

Perioperative Management Access of Peritonitis at the Regional University Hospital of Oueme-Plateau (CHUD/OP) at Porto-Novo in Benin Republic

Image Journal of Perioperative Medicine is a peer reviewed, open access periodical that underlines the importance of pre-operative medical care, procedures and protocols in assuring stress free and healthy post-operative life of the patient. Journal of Perioperative Medicine is spotlight on Local Anesthesia, Sedation, Regional Anesthesia, Anesthetic Agents, Nerve Blocks, Spinal, Epidural and Caudal Anesthesia, General Anesthesia, Thoracic Anesthesiology, Pediatric Anesthesiology, Obstetric Anesthesiology, Analgesics, Anesthesia & Critical Care, Spinal Anesthesia, Anesthetics, Epidural Anesthesia, Clinical Anesthesia, Dental Anesthesia, Vascular Anesthesia, and Surgical Anesthesia. Journal of Perioperative Medicine thus caters to a wide range... Read More

The Genetics and Genomics of Melanoma and Benign Melanocytic Neoplasms

Image This collated research topic comprises three main sections: 1) Genetic susceptibility of melanoma and benign melanocytic neoplasms; 2) genomic analysis/molecular characterization of melanoma and benign melanocytic neoplasms; and 3) biomarkers of melanoma progression. Melanoma is a malignant neoplasm that arises from melanocytes of the skin and other organs. The incidence of cutaneous melanoma, which is the most aggressive of the common skin cancers, is rapidly increasing especially in Caucasian populations. Melanocyte transformation occurs when DNA repair or cell-cycle control mechanisms are damaged, which in cutaneous melanoma, is largely due to repeated insult by ultra-violet radiation (UVR). In most cases melanocyte... Read More

Strategies in the treatment of Melanoma

Image For many years melanoma was considered a significant challenge by oncologists. In 2011 the story changed because of the approval of ipilimumab, an anti-CTLA4 monoclonal antibody, and vemurafenib, a BRAF inhibitor active on BRAF mutated melanoma. These two revolutionary drugs completely changed the management of metastatic melanoma and, for the first time, became possible to achieve a significative impact on overall survival. To improve the efficacy of ipilimumab and vemurafenib have been designed clinical trials, now ongoing, of combination with other targeted agents (e.g. MEK inhibitors) and immunotherapeutic compounds (e.g. anti-PD-L1). Other possible combinations of these two new drugs can... Read More

Prioritisation of quality indicators for elective perioperative care: a Delphi consensus

Image Journal of Perioperative Medicine publishes high-impact original work in all branches of anaesthesia, critical care medicine, pain medicine and perioperative medicine including fundamental, translational and clinical sciences, clinical practice, technology, education and training. The journal has a well-respected editorial board and provides a sharp focus on the topics and issues facing the profession of Internal Medicine with a combination of society news, clinical and scientific original articles. Journal of Perioperative Medicine is successfully running in the Volume 2 which covers a wide variety of specialties reaching out to analytical scientists worldwide. Journal of Perioperative... Read More

Relationships between Anti-mullerian Hormone, Testosterone, Luteinizing Hormone and Follicle Stimulating Hormone in Men on Testosterone Therapy

Image Clinical & Medical Biochemistry journal is a scholarly Open Access journal maintains high standards of scientific excellence and its editorial board promises a rapid peer review process with the help of the Editorial Manager System. The Journal publishes original scientific and specialized articles on all aspects of clinical and medical biochemistry, molecular medicine, clinical hematology and coagulation, clinical immunology and autoimmunity, clinical microbiology, virology, clinical genomics and molecular biology, genetic epidemiology, drug measurement, evaluation of diagnostic markers, new reagents and laboratory equipment, reference materials and methods, reference values, laboratory organization, automation, quality control, clinical... Read More

Regeneration of Cutaneous Wounds and Inflammation in Healing

Image   Cutaneous wounds are a largely unrecognized, spiraling epidemic that affects millions of people worldwide. Healing and regeneration of wounds is a complex process that has at its core a functional inflammatory response that initiates the repair process and fights against infective pathogens. Wound inflammation is a tightly regulated process involving neutrophils, macrophages, mast cells, and various leukocytes and tissue restoration mechanisms working in concert to allow healing and tissue restoration following injury. However, in many conditions, dysregulated and/or prolonged inflammation leads to the development of chronic wounds and contributes to excessive scar formation. Over the past few decades, scientific... Read More

Wound recognition across the tree of life

Image All multicellular organisms must detect injury to mount adequate responses. Plants respond with induced resistance, animals with local immunity and regeneration, and fungi exhibit wound-induced conidiation. Intact cells perceive damage-associated molecular patters (DAMPs) in the extracellular space as 'danger signals' to recognise damage before infection occurs. Molecules such as extracellular ATP and fragments of the cell wall or the extra- or intracellular matrix function as DAMPs in organisms across different kingdoms. All these DAMPs represent fragments of larger molecules or intracellular molecules. Thus, their occurrence in the extracellular space indicates the presence of damaged cells. This model, originally promoted by... Read More

Non Pharmacological Use of Daucus Carota Juice (Carrot Juice) as Dietary Intervention in Reducing Hypertension

Image The word diuresis is derived from the Greek word ourein which means ‘’to urinate’’. The diuretic agents are not only involved in the excretion of water but also capable to remove or excrete other urinary constituents which may be beneficial in the treatment of different conditions like hypertension, edema. Diuretic agents reduce morbidity and mortality related to stroke and congestive heart failure in hypertensive patients. Hypertension can be defined as sustained increase in systolic blood pressure greater than 140 mmHg and diastolic pressure greater than 90 mmHg. Generally hypertension is classified into two types, based on the causes i.e., Primary... Read More

Emerging the Field Of Enzyme Engineering

Image On behalf of our esteemed journal Enzyme Engineering (Longdom Publishers SL) is a scientific open access journal that specifies and describes the development activities conducted in the field of Medical Science. The objective of the journal is to provide a medium for scientific communication to confer about the recent advancements in Enzymology. The Editorial Board of our Enzyme Engineering Journal is overwhelmed by the response and eagerness of the academic and research contributors to publish with the journal and take part in the year-long celebrations. During this year we look forward to taking some... Read More

Impacted Cera Septal Occluder Device in Right Ventricular Outflow Tract (RVOT): A Potential Challenge for the Anesthesiologist

Image Journal of Perioperative Medicine publishes original work of high scientific quality. Preference is given to experimental work or clinical observation in man, and to laboratory work of clinical relevance. Journal of Perioperative Medicine also publishes commissioned narrative reviews by an authority in a field of interest to those working in anaesthesiology, pain, emergency medicine or intensive care. Editorials, commissioned commentaries and book reviews also included. Journal of Perioperative Medicine a wide range of articles in the discipline of anesthesiology including basic science, translational medicine, education, and clinical research to create a platform for the... Read More

Emergent needle decompression for tension pneumothorax resulting in life threatening intercostal artery injury

Image Journal of Perioperative Medicine aims to promote publications from anesthesia care providers who are otherwise unable to access other journals. Most importantly, those anesthesia care providers from countries or regions that have few resources to provide anesthesia care or approaches to perioperative medicine now have a forum to publish their approaches, research, and dilemmas in patient management. Journal of Perioperative Medicine provides a broader platform to discuss a wide range of topics in this field including Local Anesthesia, Sedation, Regional Anesthesia, Anesthetic Agents, Nerve Blocks, Spinal, Epidural and Caudal Anesthesia, General Anesthesia, Thoracic Anesthesiology,... Read More

A Pediatric Perspective on Stem Cells: Expression, Function and Clinical Relevance

Image In the last ten years, placenta, fetal membranes (i.e. amnion and chorion), and amniotic fluid have been extensively investigated as a potential non-controversial source of stem cells. They are usually discarded after delivery and are accessible during pregnancy through amniocentesis and chorionic villus sampling. Several populations of cells with multi-lineage differentiation potential and immunemodulatory properties have been isolated from the human placenta and fetal membranes; they have been classified by an international workshop as human amniotic epithelial cells (hAECs) [human amniotic mesenchymal stromal cells (hAMSCs) human chorionic mesenchymal stromal cells (hCMSCs) and human chorionic trophoblastic cells (hCTCs). In the amniotic... Read More

The Role of GroE Chaperonins in Developing Biocatalysts for Biofuel and Chemical Production

Image As the need and interest for producing renewable biofuels and biochemical has grown, new avenues to improve product yields and productivity have been explored. Specifically, improving the tolerance of host microbes towards stressors, such as heat shock or the presence of harmful solvents, has been an especially important route to improve industrial-scale chemical production. In this review, we discuss recent advances in microbial engineering for renewable chemical production through the introduction and expression of chaperonins, especially the bacterial GroE complex. The GroE complex provides a closed-off environment and allows vital proteins to enter and engage in post-translational folding or refolding... Read More

Neutrophil-mediated skin diseases: immunology and genetics

Image Neutrophil-mediated skin diseases encompass a wide spectrum of diseases characterized by polymorphic cutaneous manifestations. They are histopathologically hallmarked by sterile neutrophilic infiltrates involving the skin and, more rarely, the internal organs. Neutrophil-mediated skin diseases share clinicopathological features with those of autoinflammatory diseases, which present in patients with recurrent episodes of aseptic inflammation in the affected organs in absence of allergy or frank autoimmunity. In classic autoinflammatory diseases, mutations in genes regulating innate immune responses leads to altered activation of the inflammasome. The inflammasome is a molecular platform responsible for triggering autoinflammatory processes via the uncontrolled release of interleukin (IL)-1β, as... Read More

Inflammation in Healing and Regeneration of Cutaneous Wounds

Image Cutaneous wounds are a largely unrecognized, spiraling epidemic that affects millions of people worldwide. Healing and regeneration of wounds is a complex process that has at its core a functional inflammatory response that initiates the repair process and fights against infective pathogens. Wound inflammation is a tightly regulated process involving neutrophils, macrophages, mast cells, and various leukocytes and tissue restoration mechanisms working in concert to allow healing and tissue restoration following injury. However, in many conditions, dysregulated and/or prolonged inflammation leads to the development of chronic wounds and contributes to excessive scar formation. Over the past few decades, scientific advances... Read More

Purification Propensity for Proteins from Bacillus halodurans

Image The demand for proteins with special purposes increases significantly. These proteins are generally obtained through recombinant proteins; however their purification is costly and not easy. It is necessarily important to develop a method to estimate the chance of purification beforehand in order to have a prospective on proteins in question. Purification of a protein should be related to instinct properties of a protein including its 3D structure, and so far around 540 amino acid properties are found. Thus it is possible to test each amino acid property against the successful rate of protein purification to find out which property is... Read More

Modeling Analyses on the Success Rate of Purification of Saccharomyces cerevisiae Proteins

Image Saccharomyces cerevisiae is the most widely used yeast in research and industries, however the downstream processes for its protein production are costly. This study attempted to find out a simple way to predict the success rate of protein purification with amino acid features. Logistic regression and neural network model were used to test each of 535 amino acid features one by one against the purification state of 1294 expressed proteins from S. cerevisiae, of which 870 were purified. The results show that the predictive performance of neural network is more powerful than that of logistic regression. Some amino acid features... Read More

Impacted Cera Septal Occluder Device in Right Ventricular Outflow Tract

Image Journal of Perioperative Medicine is an open access journal that publishes highly topical clinical research relating to the perioperative care of surgical patients.  Journal of Perioperative Medicine   essence is the distillation, examination and application of clinical evidence to improve surgical outcome. Modern perioperative medicine is a true multidisciplinary speciality and the journal welcomes research in all areas relevant to perioperative medicine from any healthcare professional. Main areas of interest include but are not limited to: Perioperative outcomes (surgical, anesthetic, medical), Evidence-based care, Perioperative guidelines and consensus statements, Preoperative evaluation and risk scores, Preoperative testing,... Read More

Insights to Ultrasound Technology

Image  An ultrasound scan finds its applications in medical and research field . The ultrasound technology uses high-frequency sound waves to create images of the internal organs of the body. The major benefit of ultrasound is it does not utilize or emit any radiation that causes harm to the human body. Thus it is also suitable for use during pregnancy.An ultrasound is recommended for heart, kidneys, bladder, brain (in infants), eyes, liver, ovaries, pancreas, spleen, thyroid and other body organs. Another important application of ultrasound is found under water where an  ultrasonic pulse is generated in a specified direction . This... Read More

Torsion of Para-Ovarian Cyst

Image Single-Blind Peer Review Journal devoted to the clinical practice of anaesthesia. Journal of Perioperative Medicine a wide range of articles in the discipline of anesthesiology including basic science, translational medicine, education, and clinical research to create a platform for the authors to make their contribution towards the field without restrictions/ barriers of subscription and language. Journal of Perioperative Medicine addresses all aspects of anaesthesia practice, including anesthetic administration, pharmacokinetics, preoperative and postoperative considerations, coexisting disease and other complicating factors, cost issues, and similar concerns anesthesiologists contend with daily. Exceptionally high standards of presentation and... Read More

Sarcoidosis – the great mimicker

Image Sarcoidosis is a granulomatous disease of unclear etiology with the potential affection of major organs. It most commonly affects the lungs, skin, eyes, and lymph nodes. Less frequent, though possibly underestimated, manifestations are rheumatic and renal disease. As a systemic disease, it can present in numerous ways and mimic many other conditions, including infections and cancer. While it has been proposed that an abnormal immunologic response to antigens leads to granulomatous inflammation in genetically predisposed individuals, much has to be learned. Sarcoidosis can present as an acute and self-limiting disease or progress to a chronic and potentially debilitating disorder. The... Read More

Advance In B-cell therapies for the Treatment of Rheumatic Disease

Image B-cells have multiple pathogenic roles in rheumatic and musculoskeletal diseases (RMDs). The two most evaluated strategies for B-cell blockade over the last two decades are B-cell depletion and inhibition of B-cell survival factors (BAFF and/or APRIL). Rituximab, a chimeric monoclonal antibody depletes B-cells by targeting CD20, although the depth, duration of depletion and clinical response may vary between patients. Recent data have supported the efficacy of reduced rituximab dose and the different retreatment strategies in both its licensed indications; rheumatoid arthritis and granulomatosis with polyangiitis/microscopic polyangiitis, although long-term data are still needed to establish the optimal approach. Despite the failure... Read More

Cephalosporin C Production from Acremonium chrysogenum

Image Cephalosporin C demand is increasing worldwide because of its enhanced antibacterial spectrum that it can be used to treat diseases and infections caused by Gram positive/or Gram negative bacterial strains. Cephalosporin C is easily produced from the fungus Acremonium chrysogenum by the process of fermentation in a bioreactor under optimum reaction conditions to obtain maximum yield of the antibiotic. Additional chemical and structural modifications in the existing cephalosporin C could further enhance its antimicrobial spectrum. Acremonium chrysogenum also known as Cephalosporium acremonium is the industrial producer of the antibiotic cephalosporin C, a beta-lactam antibiotic. Today cephalosporin and its derivatives are... Read More

Protein–Protein Interaction

Image Protein–protein interactions (PPIs) are the physical contacts of high specificity established between two or more protein molecules as a result of biochemical events steered by interactions that include electrostatic forceshydrogen bonding and the hydrophobic effect. Many are physical contacts with molecular associations between chains that occur in a cell or in a living organism in a specific biomolecular context Proteins rarely act alone as their functions tend to be regulated. Many molecular processes within a cell are carried out by molecular machines that are built from numerous... Read More

Management of On-going Antiplatelet Treatment in Elderly Patients

Image Journal of Perioperative Medicine is a peer reviewed, open access periodical that underlines the importance of pre-operative medical care, procedures and protocols in assuring stress free and healthy post-operative life of the patient. Journal of Perioperative Medicine aims to publish the most reliable and complete information on discoveries and current developments in the form of research articles, review articles, case reports and short communication. All articles are peer reviewed and published under the guidance of our Editorial Board members. The published articles are made freely and permanently accessible online immediately upon publication, thus improving... Read More

Anaesthesia and Perioperative Care

Image Journal of Perioperative Medicine (JPME) is an international, peer reviewed, open access journal committed to publish innovative research in the field of anaesthesia and pain medicine. Anaesthesia means temporary ‘loss of sensation or awareness' usually given as gas to breathe in, injections, ointments, drops or sprays to stop the painless performance of medical procedures. It is usually given as gas to breathe in, injections, ointments, drops or sprays. Journal of Perioperative Medicine provides a broader platform to discuss a wide range of topics in this field including Local Anesthesia, Sedation, Regional Anesthesia, Anesthetic Agents,... Read More

Enzyme Expression

Image The metabolic enzyme expression remodelling is now widely known as hallmark of cancer, but it is not clear whether individual metabolic strategies are frequently exploited by many tumours. The highest scoring pathway is mitochondrial one-carbon metabolism and protein are markedly elevated in many cancers and correlated with poor survival in breast cancer. In this it shows the importance of mitochondrial compartmentalization of one carbon metabolism in cancer and raises important therapeutic hypotheses. Enzymes are an important staple in the biopharmaceutical, agricultural and chemical fields. However, expression of these workhorse proteins comes with a number of problems as well. Bacterial hosts... Read More

Bioprocess

Image A bioprocess is a specific process that uses complete living cells or their components (e.g., bacteria, enzymes, chloroplasts) to obtain desired products. Transport of energy and mass is fundamental to many biological and environmental processes. Areas, from food processing (including brewing beer) to thermal design of buildings to biomedical devices to pollution control and global warming, require knowledge of how energy and mass can be transported through materials (momentum, heat transfer, etc.). Cell bioprocessing: Cell therapy bioprocessing is a discipline that bridges the fields of cell therapy and bioprocessing (i.e., biopharmaceutical manufacturing), and is a sub-field of bioprocess engineering.... Read More

Biomaterials for Skin Wound Repair

Image It is often overseen that the skin or integument is the biggest organ of the human body. Moreover, skin importance spans different fields, from esthetics and social interactions to various diseases and their multiple upshots. Notably, skin and internal organs are bidirectionally related: an organ disease can alter skin structure and function, and vice versa. An example of this mutual relationship is acute or chronic urticaria (hives) with or without angioedema, which affects wide skin areas and is caused by immune reactions to foreign antigens, autoimmunity, malignancy, and so on. The reverse example is a deep and extended burn wound... Read More

Hair Follicle Stem Cell Regeneration in Aging

Image Tissues and organs undergo structural and functional declines in the aging process, with a gradual decrease in regenerative ability. The hair follicle is a complex mini-organ that undergoes cyclic self-renewal during postnatal life, as the follicle contains stem cells that can be activated and silenced cyclically. Thus, it serves as an excellent model for studying regeneration. However, follicles gradually lose hairs and stem cells enter quiescence or differentiate into other skin epithelial lineages during aging. This process is largely influenced by intrinsic epigenetic status and extrinsic environmental factors which affect the hair follicle stem cell behavior during hair cycling. In... Read More

Malassezia: A Skin Commensal Yeast Impacting Both Health And Disease

Image Malassezia yeast existS on all humans and have long been associated with healthy and diseased skin. In this Article Collection of Frontiers in Cellular and Infection Microbiology; Fungal Pathogenesis, we will present multiple papers outlining the state of the art in understanding the role Malassezia in skin health and disease. Over the last thirty years, the term “microbiome” has grown exponentially in scientific discourse, generating hundreds of thousands of publications and patents. Although the human-associated microbial community consists of bacteria, fungi, viruses, and archaea, the vast majority of these publications have been limited to gut bacteria. Only in the two... Read More

Genetics in Human Skin Diseases

Image Over the past decades, large numbers of genes and genomic regions involved in human complex diseases have been revealed through linkage analysis, candidate gene study, and genome-wide linkage study. These help to determine the position of the genetic marker inherited with a complex disease. Since 2005, genome-wide association studies (GWAS) have been proved to be the most powerful and efficient study design for identifying genetic variants that are associated with complex diseases. More than twenty kinds of skin diseases and traits have been investigated by this approach including psoriasis, SLE, leprosy, vitiligo, and atopic dermatitis. Recently, Next-Generation DNA Re-Sequencing and... Read More

The Role of Enzymes in Metabolism

Image Metabolism is chemical reactions occurring in organisms. Without enzymes metabolism wouldn’t be fast enough to support life. Metabolism refers to all the chemical reactions occurring in organisms. Chemical composition: Enzymes are made of protein. Protein consists of one or more polypeptide chain. These are made of long chains of amino acids connected by peptide bonds. Structure of Enzymes: In enzymes, the polypeptide chain is folded into a 3D shape. A part of the enzyme is called the active site. This attaches to the substrate The substrate is molecules the enzymes act upon. Specific of enzymes: ... Read More

Role of Enzymes in Detergents

Image The original idea of using enzyme as detergents was described in 1913 by Dr Otto Rohm, who patented the use of crude pancreatic extracts in laundry pre-soak compositions to improve the removal of biological stains. In the same year, the first enzymatic detergent named Burnus was launched, but was not popular because of its own limitations. Subsequently, Bio- 40 - a detergent containing a bacterial protease was produced in Switzerland and launched in the market in1959 and it gradually became popular. In the period from 1965 to 1970, use and sale of detergent enzymes grew very fast. In 1970, the... Read More

Potential Challenge for the Anaesthesiologist

Image Journal of Perioperative Medicine is multidisciplinary medical field related to perioperative care of surgical patients. Journal of Perioperative Medicine is medical patient care from the time of contemplation of surgery to recuperate from surgical period to improve the surgical outcome. Surgeon, anesthetist, intensivist and physician work closely in such field. However anesthetist play major role in perioperative medicine from pre anesthesia check prior to surgery. Journal of Perioperative Medicine provides a broader platform to discuss a wide range of topics in this field including Local Anesthesia, Sedation, Regional Anesthesia, Anesthetic Agents, Nerve Blocks, Spinal,... Read More

Biochemical Changes and Cardiovascular Function

Image Clinical & Medical Biochemistry  covers the research areas in the field of Clinical Biochemistry, Pathological, Microbiological, Molecular, Cellular, Genetic and Bioinformatics concepts and other advanced techniques. The journal primary mission to serve the public interest in health care by providing leadership in clinical laboratory science to national professional societies, the diagnostics industry, government and non-government organization. Journal of Clinical and Medical Biochemistry also acts as a bridge in various interdisciplinary areas of medicine. It covers laboratory accreditation programmes pertaining to health and disease. Clinical biochemistry is a special branch of medicine dealing with measurement... Read More

Recent Advances in Clinical Enzymology

Image The past year has seen a wider application of knowledge originating over the last decade rather than startling new developments. For brevity, only serum enzymes will be considered and the points at which progress is being made are indicated by the sectional headings which follow. ENZYME METHODOLOGY: Considerable change is taking place in established enzyme methods and new forms of methodology are being developed. Colorimetric kinetic assays Together with the familiar ultraviolet (UY) kinetic assays, newer kinetic assays utilising wavelengths in the visible part of the spectrum are proving increasingly popular. They have been rendered possible by the increasing... Read More

Call for Research Papers-Enzyme Engineering

Image Enzyme Engineering [EEG] is a peer-reviewed journal that offers researchers and scholars in-depth useful reviews and research trials and surveys of new and novel approaches in the field of Enzymology and Clinical Sciences. Each peer-reviewed issue assesses practice issues; practice settings; therapeutics issues; disease management; the latest research; as well as issues arising from today’s emerging health-care research. Journal Aim EEG was started with an aim to support the wider scientific community working in the field of Enzymology and associated disciplines. It looks forward to provide the academicians, researchers and future generations a forum to publish... Read More

Cutaneous B-cell Lymphomas

Image Primary cutaneous lymphomas (PCLs) are non-Hodgkin lymphomas that are present only in the skin at the time of diagnosis, and without evidence of extracutaneous manifestations. Among extranodal non-Hodgkin lymphomas, PCLs are the second most frequently observed type after gastrointestinal lymphomas. PCLs occur at an incidence of 1 per 100,000 persons annually, and about 25% to 30% of all are Cutaneous B-cell lymphomas (CBCLs). CBCLs can be further classified according to clinical behavior as either aggressive or indolent. Indolent CBCLs include primary cutaneous marginal zone lymphoma (PCMZL) and primary cutaneous follicle center lymphoma (PCFCL), whereas the aggressive CBCLs are diffuse large... Read More

Application of Computed Tomography on Bovine and Malignant Tumors

Image Journal of Molecular Imaging & Dynamics is glad to disseminate knowledge on the “Computed Tomography: A Reliable Modality for the Assessment of Bowel Wall Thickening to Categorize Benign and Malignant Lesions of Bowel WallGist of the study : Presently, CT is considered the first-line modality for the evaluation of a variety of small and large bowel diseases. A wide spectrum of intestinal wall morphologic and enhancement abnormalities can be seen with bowel disorders. Once an abnormality is detected, the radiologist needs a systematic approach for determining the specific cause of... Read More

Evaluation of the Ophthalmology

Image Publishing highly topical clinical research relating to the perioperiative care of surgical patients, Journal of Perioperative Medicine  aims to disseminate the distillation, examination and application of clinical evidence to improve surgical outcome. Understanding that modern perioperative medicine is a multidisciplinary speciality, we welcome research in all areas relevant to perioperative medicine from any healthcare professional. Journal of Perioperative Medicine is an informative professional journal which provides current evidence-based practice, clinical, management and educational developments for practitioners working in the perioperative environment. The journal promotes perioperative practice by publishing clinical research-based articles, literature reviews, topical... Read More

Nursing, Education and Perioperative Care

Image Journal of Perioperative Medicine is an open access journal that publishes highly topical clinical research relating to the perioperative care of surgical patients. Its essence is the distillation, examination and application of clinical evidence to improve surgical outcome. Modern perioperative medicine is a true multidisciplinary speciality and the journal welcomes research in all areas relevant to perioperative medicine from any healthcare professional. Journal of Perioperative Medicine  focusing on technologies, medical devices, apps, engineering, informatics and patient education for perioperative medicine and nursing, including pre- and post-operative education, preventative interventions and clinical care for surgery... Read More

Aspiring good health of Mother and Neonate

Image  Journal of Pregnancy and Neonatal Medicine is an online open access journal considers articles on all aspects of pregnancy and childbirth. Journal of Pregnancy and Neonatal Medicine includes the focusing on all the aspects of pregnancy, breastfeeding, labour, maternal health, maternity care, trends and sociological aspects of pregnancy and childbirth. Journal of Pregnancy and Neonatal Medicine is the practical, research-based journal for all professionals concerned with the care of neonates and their families, both in hospital and the community. JPNM aims to support the development of the essential practice, management, education and health promotion... Read More

Scope and Growth of Perioperative Medicine

Image   Perioperative medicine encompasses the care of the patient preparing for, having and recuperating from surgery. In the practice of perioperative medicine the surgeon, anaesthesiologist , intensivist and medical consultant work in concert. The medical knowledge distinct to this field includes that of operative risk and complications, of patient specific risks, of methods to reduce risk, and of the management of medical illness during this time period. Evidence supporting best practices in perioperative medicine is expanding, though historically this field has been directed by common practice and experience. It remains a field governed primarily... Read More

Clinical and Medical aspects of Biochemistry

Image Journal of Clinical and Medical Biochemistry (cmbo) is a journal which publishes original research communications, review articles, case reports, letters to the editor in the field of medical biochemistry and laboratory medicine. The objective of the journal is to publish novel information leading to a better understanding of biochemical mechanisms behind the pathogenesis, diagnosis, and management of human diseases. Journal of Clinical and Medical Biochemistry publishes original scientific and specialized articles on all aspects of clinical chemistry, medical biochemistry and related scientific disciplines where chemistry, biochemistry, molecular biology and immunochemistry are dealing with the... Read More

Biochemistry and Medical Science

Image Medical Biochemistry is a branch of medicine that represents a unique integration of basic biochemical science and clinical medicine. In addition to acting as an effective consultant for clinical colleagues, medical biochemists are trained with the knowledge and skills necessary to operate and manage clinical biochemistry laboratories. The practice of medical biochemistry is privileged to be in tertiary care centres’, as part of a multidisciplinary team including scientists and technologists. Journal of Clinical & Medical Biochemistry covers all the fields of Clinical & Medical Biochemistry related to Clinical biochemistry, Immunology, Genetics,... Read More

Affectivity beyond the Skin

Image This Research Topic will be an interdisciplinary collection of papers by philosophers, psychologists and social scientists. The proposed topic is an exploration of the scaffolded or environmentally supported nature of affectivity. Standard approaches in philosophy and psychology characterize affective states (such as specific emotions and moods) as states of a person’s brain and body. This Research Topic will explore the extent to which affective states also importantly depend upon structures and processes in the environment. In particular, it will explore the way in which people actively manipulate their surroundings to create what we can call affective niches: self-styled environments that... Read More

Applications of Enzymes in Our Daily Life

Image Here are some examples of enzyme biotechnology you might use every day in your own home. In many cases, the commercial processes first exploited naturally occurring enzymes. However, this does not mean the enzyme(s) being used were as efficient as they could be.With time, research, and improved protein engineering methods, many enzymes have been genetically modified. These modifications allow them to be more effective at the desired temperatures, pH, or other manufacturing conditions typically unsuitable for enzyme activity (e.g. harsh chemicals). They are also more applicable and efficient for industrial or home applications. I. Application in feed The use of... Read More

Enzyme Engineering: Explore your Research Work-New Edition

Image Enzyme Engineering [EEG] is a peer-reviewed journal that offers researchers and scholars in-depth useful reviews and research trials and surveys of new and novel approaches in the field of Enzymology and Clinical Sciences. Like the Anesthesia research, topics are diverse. Recent topics have included focussing on Enzyme Research: Bioprocess Cross Linking Enzyme Expression Enzyme Kinetics Insilco Design of Enzymes Protein Interaction Protein Peptide Interactions Computation Protein Design Enzyme Catalyst Enzyme Immobilisation Enzyme Purification Ionic Bonding Protein Ligand Binding Protein-Protein Complexes Covalent Binding Enzyme Engineering Enzyme Inhibition Enzymes Metabolic Pathway Engineering Protein Nucleotide Each peer-reviewed issue assesses practice... Read More

Tactile Stickiness Perception

Image "The bandage keeps coming off my arm, but it definitely sticks to my fingertip." Some people might have a similar experience. From this phenomenon, we can bring up several interesting questions. Why does the stickiness vary from location to location on the skin? What information is computed from the sticky surface elements and how? What is the relationship between physical and perceptual stickiness? Unfortunately, at the moment, little information is mounted to answer these questions. Previous studies revealed that the tactile sense of stickiness is aroused when the skin is stretched as people detach their body from an adhesive substance.... Read More

Insights into Biomarkers, Cytokines, and Chemokines in Skin Cancer

Image Understanding the microenvironment within skin cancers is key for the development of new preventative and therapeutic treatment options. Research advances in skin cancers such as melanoma have revolutionized immunotherapeutic treatment options, for example through the provision of checkpoint inhibitor trials that have benefitted not just melanoma patients, but also patients with a wide array of other cancers, including less readily accessible cancer types. However, checkpoint inhibitor success is limited in melanoma and unlikely to become the mainstay of treatment for other skin cancer types like squamous cell carcinoma. Therefore, many skin cancer subtypes remain with few treatment options and there... Read More

Medical Biochemistry and Its Applicative Arm

Image The Journal of Clinical and Medical Biochemistry publishes original scientific and specialized articles on all aspects of clinical and medical biochemistry, molecular medicine, clinical haematology and coagulation, clinical immunology and autoimmunity, clinical microbiology, virology, clinical genomics and molecular biology, genetic epidemiology, drug measurement, evaluation of diagnostic markers, new reagents and laboratory equipment, reference materials and methods, reference values, laboratory organization, automation, quality control, clinical metrology, all related scientific disciplines where chemistry, biochemistry, molecular biology and immunochemistry deal with the study of normal and pathologic processes in human beings. Journal of Clinical and Medical Biochemistry... Read More

Science and Forensic Medicine

Image Journal of Forensic Medicine (JFM) publishes topical articles on aspects of forensic and legal medicine. Specifically the Journal supports research that explores the medical principles of care and forensic assessment of individuals, whether adult or child, in contact with the judicial system. It is a fully peer-review hybrid journal with a broad international perspective. Journal of Forensic Medicine (JFM) is a peer reviewed journal, serving the International Scientific Community. This forensic medicine journal with impact factor offers an Open Access platform to the authors to publish their research outcome. Journal of Forensic Medicine(JFM) is... Read More

Care of the Mother and Neonate

Image   Journal of Pregnancy and Neonatal Medicine(JPNM) is an open access, peer reviewed, scholarly journal that focusses on the publication of research developments in the various aspects of fertility, pregnancy, child birth and neonatal care. Pregnancy and neonatal medicine research are of high significance and it is indispensable for assuring the good health of new mothers and babies. Journal of Pregnancy and Neonatal Medicine(JPNM) integrates both the topics and aims towards contributing in the furtherance of research in the field of obstetric medicine and neonatal medicine. Journal of Pregnancy and Neonatal Medicine(JPNM) publishes a... Read More

Development and testing of perioperative medicine

Image Journal of Perioperative Medicine (JPME) is an open access journal that publishes highly topical clinical research relating to the perioperative care of surgical patients. Its essence is the distillation, examination and application of clinical evidence to improve surgical outcome. Modern perioperative medicine is a true multidisciplinary speciality and the journal welcomes research in all areas relevant to perioperative medicine from any healthcare professional. Journal of Perioperative Medicine provides a broader platform to discuss a wide range of topics in this field including Local Anesthesia, Sedation, Regional Anesthesia, Anesthetic Agents, Nerve Blocks, Spinal, Epidural and... Read More

Combination strategies in the treatment of Melanoma

Image For many years melanoma was considered a significant challenge by oncologists. In 2011 the story changed because of the approval of ipilimumab, an anti-CTLA4 monoclonal antibody, and vemurafenib, a BRAF inhibitor active on BRAF mutated melanoma. These two revolutionary drugs completely changed the management of metastatic melanoma and, for the first time, became possible to achieve a significative impact on overall survival. To improve the efficacy of ipilimumab and vemurafenib have been designed clinical trials, now ongoing, of combination with other targeted agents (e.g. MEK inhibitors) and immunotherapeutic compounds (e.g. anti-PD-L1). Other possible combinations of these two new drugs can... Read More

New Trends in Journal of Developing Drugs

Image Journal of Developing Drugs is an open access publishing that aims to focus on the Drugs, and also related to Chemistry and Pharmacy. Journal of Developing Drugs deals with chemical compounds found in Drugs that usually has a pharmacological or biological activity for use in pharmaceutical drug discovery and drug design. Articles such as original research papers, review articles, short communications, case reports and commentaries are welcome. Articles related to Drug Metabolism, Drug Designing, Clinical Trails, Drug Discovery, Biopharmceutics, Pharmacokinetics and Pharmacodynamics of the Drugs. The main aim of the Journal of Developing Drugs and Research is to publish high... Read More

Enzymes and its Role

Image Enzymes are known to catalyze more than 5,000 biochemical reaction types.Other biocatalysts are catalytic RNA molecules, called ribozymes. Enzymes' specificity comes from their unique three-dimensional structures. Enzymes are sensitive to external conditions and therefore have unstable characteristics. High temperature, strong acid, alkali and some heavy metal ions will lead enzyme to lose activity and useless. Enzymes are generally difficult to preserve, which brings great difficulties to a wide range of applications. According to the function of the enzyme, enzymes are usually divided into six categories: A. oxidoreductases, including sub-oxidase and dehydrogenase, which are involved in productivity, detoxification and the synthesis... Read More

Enzymes and its Evolution

Image Enzyme is a kind of catalytic protein produced in the body, functioning as a catalyst. The catalyst can accelerate the chemical reaction without the change of amount and chemistry after the chemical reaction. All enzymes are macromolecules made up of many amino acids with a molecular weight between 10,000 and 1,000,000. Natural enzyme molecules include simple enzymes and binding enzymes. The former molecular composition contains only protein, the latter contains non-protein components, as well as protein composition. Some also contain metal ions. Non-protein components in enzymes are known as cofactors. The combination of cofactors and enzyme proteins is called holoenzyme.... Read More

Biomedical Research: Grab and bag huge citations with BMR

Image Biomedical Research: Grab and bag huge citations with BMR Biomedical Research (BMR) is a peer-reviewed journal that offers researchers and scholars in-depth useful reviews and research trials and surveys of new and novel approaches in the field of Biological and medical sciences. Like the biomed research, topics are diverse. Recent topics have included focussing on Thyroid Research: Goiter Graves’ Disease Hashimotos Thyroiditis Hyperthyroidism Hyperthyroidism Symptoms Hypothyroidism Hypothyroidism Symptoms Iodine Deficiency Iodine Supplements Levothyroxine Parathyroid Hormone Thyroid Cancer Thyroid Gland Thyroid Nodules Thyroid Symptoms Thyroid Test Thyroid Treatment Thyroidectomy Thyrotoxicosis Thyroxine TSH Levels TSH Test Each... Read More

Sleep and Aging

Image Life expectancy is on the rise worldwide. Within the US alone, it is estimated that 20% of the population will be over the age of 65 years by 2030. Normal aging results in a relentless deterioration of both sleep and wakefulness. This includes sleep fragmentation and the inability to sustain wakefulness during the active phase in humans and rodents. Impairments in both behavioral states become more pronounced in many age-dependent neurodegenerative processes. Impaired wakefulness interferes with cognitive function and quality of life for millions of older Americans. Recent data indicates that sleep disruption and disorders might themselves contribute to the... Read More

Skin Blistering Diseases

Image Skin blistering is commonly caused by mechanical, physical or infectious insults. More rarely, mutations of structural components of the skin or autoimmunity directed against those structural components lead to skin blistering. Skin blistering is commonly caused by mechanical, physical or infectious insults. More rarely, mutations of structural components of the skin or autoimmunity directed against those structural components lead to skin blistering. Albeit among the less frequent causes of skin blistering, understanding of the pathomechanisms of hereditary and autoimmune skin blistering has provided detailed insights into cutaneous biology and (auto)immunity. In recent years, genetics, definition of autoantigens, model systems and... Read More

The Infinite Possibilities of Enzyme Engineering

Image Protein engineering is a powerful tool in synthetic biology that can create proteins with tremendous potential for therapeutic and industrial use. The field has recently taken giant leaps forward from its origins, and some of its pioneers predict that the next five to ten years hold exponentially more promise. Early protein engineering was what David Baker, Ph.D., director of the Institute for Protein Design at the University of Washington, called “Neanderthal protein design.” “You’d look around in nature for something where you could make a couple of amino acid substitutions.  It’s like when early humans needed a tool, they’d sharpen... Read More

Applications of Enzyme Engineering for Better World

Image Engineered proteins can be used to optimize desired traits in plants; even though recent advances have resulted in new application areas, certain methodological challenges remain. Protein engineering and directed evolution are powerful technologies for probing protein sequence-function relationships. These methods have been used to engineer both plant-derived proteins and exogenous proteins heterologously expressed in plants. In this review, we aim to further increase the interdisciplinary crossover between the disciplines of protein engineering and plant biology by first introducing protein engineering in some detail. This introduction is key to understanding current limitations to protein engineering when applied to plants. Subsequently, we... Read More

Biologic Drugs in Autoimmune Diseases

Image In the current therapy of autoimmune disease, a significant progress has been made in terms of introducing novel, mostly biologic, drugs in place of chemical molecules. These biologic agents enhance or replace conventional immunosuppressive therapies. Their mechanism of action consists in disrupting the inflammatory process. The categories of biologics include inhibitors of tumor necrosis factor, interleukins, T cells, B cells, or JAK. Biologics, or biologic-response modifiers, may be prescribed for the treatment of autoimmune diseases, including many types of arthritis (e.g., rheumatoid arthritis, ankylosing spondylitis, and psoriatic arthritis), as well as inflammatory bowel diseases or psoriasis. Biologics exert significant clinical... Read More

Resveratrol and Breast Cancer (STUDY)

Image Researchers demonstrate that resveratrol, the ingredient which is found in red wine, prevents the growth of breast cancer cells by stopping the growth effects of estrogen. These study results suggest that resveratrol is capable of counteracting the malignant progression as it suppresses the spreading of hormone resistant breast cancer cells. The discovery has significant implications for treating breast cancer in women whose tumors at some point develop a resistance to hormonal therapy. The researchers made use of a number of breast cancer cell lines that express the estrogen receptor in order to evaluate the effects of resveratrol. The different cells... Read More

Type 2 Diabetes Drugs and Pancreatic Cancer Association

Image According to a study, 2 drugs made use of for treating type 2 diabetes may be associated with a significantly higher risk of the development of pancreatic cancer and pancreatitis, and 1 of the drugs may be associated with an increased thyroid cancer risk. Researchers analyzed the FDA’s database for adverse events reported by individuals making use of the type 2 diabetes drugs exenatide and sitagliptin. A 6 times the increase in the odds ratio for reported pancreatitis cases with these drugs was found, in comparison to 4 other diabetes control therapies. It was also found that individuals using the... Read More

Autoinflammatory Keratinization Disease (AiKD)

Image As the research in the field of Dermatology has been increasing day-by-day, the clinical investigations and trails are also been advanced. Inflammation caused by the hyper-activation of innate immunity due to genetic factors occasionally leads to inflammatory keratinization diseases of the skin. Such inflammatory keratinization diseases with genetic autoinflammatory pathogeneses are called “autoinflammatory keratinization diseases” (AiKD). AiKD also includes diseases with mixed pathological mechanisms of autoinflammation and autoimmunity. AiKD have primary genetic causative factors associated with autoinflammation mainly in the epidermis and the upper dermis. Autoinflammation in the epidermis and the upper dermis leads to hyperkeratosis in the skin, resulting... Read More

Call from Enzyme Engineering: Open-Access (Volume 8: Issue: 2)

Image Enzymes have played an important role in many aspects of life since the dawn of time. In fact they are vitally important to the existence of life itself. Civilizations have used enzymes for thousands of years without understanding what they were or how they work. The French chemists Anselme Payen and Jean-Franois Persoz described the isolation of an amylase complex from germinating barley and named it diastase. Like malt itself, this product converted gelatinized starch into sugars, primarily maltose. In 1835 the Swedish chemist Jöns Jacob Berzelius demonstrated that starch can be broken down more efficiently using... Read More

Scope of Enzyme Engineering for Better Science World

Image Our Journal Enzyme Engineering (Longdom Publishers SL) is an esteemed Monthly, Peer reviewed and Open-Access journal that focuses on recent innovative inventions and recent advancements in the field of enzymology and enzyme engineering. Our journal promulgates all current issues that take place in betterment in the field of Life sciences. The Editorial Board of our journal is overwhelmed by the response and eagerness of the academic and research contributors to publish with the journal and take part in the year-long celebrations. During this year we look forward to taking some initiatives that would encourage... Read More

Skin Autoimmunity

Image In the last few decades, autoimmune diseases have become a major clinical burden. The reasons for this are manifold, including (i) increasing incidence; (ii) the lack of therapies that target the underlying cause of the specific disease in question and (iii) the high rate of adverse events due to prolonged, unspecific immunosuppression. The skin is one of the largest organs of the human body and several autoimmune diseases manifest at the skin. These include skin-specific autoimmune diseases and cutaneous manifestations of systemic autoimmune diseases. Furthermore, with the recent success of immune checkpoint therapy in cancer, immune-mediated adverse effects on the... Read More

Cosmeceuticals from Medicinal Plants

Image If "drugs" have been defined as compounds used in the treatment and prevention of diseases, or are intended to affect a physiological function, "cosmetics" have been labelled as substances that clean or enhance the appearance of the skin without therapeutic benefits. There is also a grey area bordering these two fields, for which the term "cosmeceuticals" has been defined. “Cosmeceuticals” are described as hybrids between drugs and cosmetic products which are able to enhance both health and beauty of the skin by external application. Cosmeceuticals, bridge the gap between pharmaceuticals, skin diseases and cosmetics. ‘Cosmeceuticals’ are topical cosmetic-pharmaceutical hybrids intended... Read More

Join our Editorial Board - Chemotherapy: Open Access

Image Chemotherapy: Open Access (CMT) [ISSN: 2167-7700, Index Copernicus Value: 62.73] is one of the best Open Access journals publishes the relevant and reliable information on the discoveries and current developments and all other areas of the field and making them freely available online without any restrictions or any other subscriptions to researchers worldwide. The journal provides multi-disciplinary interpretation of the latest research advances in different aspects of therapeutic techniques such as Cytotoxic, Electro, and the antimicrobial chemotherapies used to treat several dreadful diseases, particularly Cancer. It also accepts... Read More

Chemotherapy: Open Access - Call for Papers

Image Chemotherapy: Open Access (CMT), is one of the best Open Access journals publishes the relevant and reliable information on the discoveries and current developments in the form of original articles, review articles, case reports, short communications, etc. and all other areas of the field and making them freely available online without any restrictions or any other subscriptions to researchers worldwide. Journal expresses its warm gratitude to especially the Editorial Board, and extending this gratitude to all the Authors, researchers, Editors and Students who have contributed their valuable researches in the form of full article, case reports to... Read More

Call to Join as Editorial Board Member :Enzyme Engineering|Open-Access

Image Our Journal Enzyme Engineering (Longdom Publishers SL) is an esteemed Monthly, Peer reviewed and Open-Access journal that focuses on recent innovative inventions and recent advancements in the field of enzymology and enzyme engineering. Our journal promulgates all current issues that take place in betterment in the field of Life sciences. The Editorial Board of our journal is overwhelmed by the response and eagerness of the academic and research contributors to publish with the journal and take part in the year-long celebrations. During this year we look forward to taking some initiatives that would encourage... Read More

Expertise your Research to Enzyme Engineering for Better Science

Image Our Journal Enzyme Engineering (Longdom Publishers SL) is an esteemed Monthly, Peer reviewed and Open-Access journal that focuses on recent innovative inventions and recent advancements in the field of enzymology and enzyme engineering. Our journal promulgates all current issues that take place in betterment in the field of Life sciences. The Editorial Board of our journal is overwhelmed by the response and eagerness of the academic and research contributors to publish with the journal and take part in the year-long celebrations. During this year we look forward to taking some initiatives that would encourage... Read More

Types of Chemotherapy - Chemotherapy: Open Access (Special Edition)

Image Antitumor Antibiotics Antitumor antibiotics are chemo treatments made of natural merchandise made by species of the soil plant life actinomycete.  These medication act throughout multiple phases of the cell cycle and are thought of cell-cycle specific.  There are many forms of growth antibiotics: Anthracyclines: antibiotic, Daunorubicin, Epirubicin, Mitoxantrone, and Idarubicin. Chromomycins:  Dactinomycin and Plicamycin. Alkylating Agents Alkylating agents are most active within the resting section of the cell.  These forms of medication are cell-cycle non-specific.  There are many forms of alkylating agents utilized in therapy treatments: Poison gas derivatives:  Mechlorethamine, Cyclophosphamide, alkalating agent, Melphalan, and Ifosfamide. Ethylenimines:... Read More

Invitation for Article Submission - Chemotherapy: Open Access

Image [ISSN: 2167-7700 | Index Copernicus Value: 62.73] Greetings from Chemotherapy: Open Access! Chemotherapy: Open Access is a prestigious Journal publishing Cancer and Chemotherapy research Articles. This unique Journal aims to publish complete and reliable source of information on the discoveries and current developments in the field of Cancer and Chemotherapy. Journal deals with various types of therapeutic techniques such as Cytotoxic, Electro, and the antimicrobial chemotherapies used to treat several dreadful diseases, particularly Cancer. It also accepts articles on immune suppressant and its application along with different aspects of chemotherapy research and chemotherapy reviews. This scientific journal... Read More

Skin Functions and Mechanisms

Image The search for further knowledge on skin functions and mechanisms is at the core of many biomedical and biopharmaceutical research programs today. The extension and complexity of the skin justifies its multiple roles, affecting all physiological processes, far beyond its “barrier” characteristics. More research on skin physiology is needed to better understand various disease mechanisms, and these need not be confined to the skin itself. Skin is also a target for new molecules, supplements, materials and even instruments, with the potential to impact the whole body. Because of its accessibility and relative dimension, it is also a model to study... Read More

Pancreatic Disorders Journal Aiming at Pancreatitis

Image On behalf of the Pancreatic Disorders & Therapy, as Editor, it is my distinct honour and privilege to inform you that, it’s been eight years we have started the Journal, now we are celebrating them 8th Anniversary and we are privileged to welcome researchers of pancreatic Disorders to our journal. As Editor it is my great pleasure and honour to welcome you to the Pancreatic Disorders & Therapy. The Journal of Pancreatic Disorders & Therapy  aims to disseminate knowledge and promote discussion through the publication of peer-reviewed, high quality research papers on all topics related to Chromatography.... Read More

Disorders in Pancreatics & Therapy

Image Pancreatic Disorders & Therapy is a peer reviewed medical journal that includes a wide range of topics in this field and creates a platform for the authors to contribute towards the journal. The editorial office promises to peer review the submitted manuscripts to ensure quality PDT is one of the best open access journal that aims to publish the most complete and reliable source of information on discoveries and current developments in the mode of original articles, review articles, case reports, short communications, etc. in this field and provides online access to the researchers worldwide without any... Read More

Recent Trends in Enzymes and Technology

Image Our Journal Enzyme Engineering (Longdom Publishers SL) is an esteemed Monthly, Peer reviewed and Open-Access journal that focuses on recent innovative inventions and recent advancements in the field of enzymology and enzyme engineering. Our journal promulgates all current issues that take place in betterment in the field of Life sciences. The Editorial Board of our journal is overwhelmed by the response and eagerness of the academic and research contributors to publish with the journal and take part in the year-long celebrations. During this year we look forward to taking some initiatives that would encourage... Read More

Recent Trends in Enzyme Engineering

Image Our Journal Enzyme Engineering (Longdom Publishers SL) is an esteemed Monthly, Peer reviewed and Open-Access journal that focuses on recent innovative inventions and recent advancements in the field of enzymology and enzyme engineering. Our journal promulgates all current issues that take place in betterment in the field of Life sciences. The Editorial Board of our journal is overwhelmed by the response and eagerness of the academic and research contributors to publish with the journal and take part in the year-long celebrations. During this year we look forward to taking some initiatives that would encourage... Read More

Inviting you to Join as an Editorial Board: Open Access Journal

Image Inviting you to Join as an Editorial Board: Open Access Journal    “Journal of Thyroid Disorders & Therapy” offers the most comprehensive and reliable information pertaining to the latest developments in the field. The Journal also believes in advancing new hypotheses and opinions by means of its high-quality Reviews, Perspectives, and Commentaries. Thus, the content published in the journal is original and comprehensive. Manuscripts are subjected to rigorous peer review, where acclaimed scientists that are part of the editorial board are involved in this process to add value to the research findings. The impartial and transparent review process ensures the... Read More

Journal of Depression and Anxiety accomplished 8 Years Milestone in Research Publication Journey

Image Journal of Depression and Anxiety glad to invite eminent researchers to submit their valuable research for the final issue of Volume 8 in the year 2019. On-behalf of our editorial board we welcome original research, review, case reports, opinions, editorial, image articles, commentary articles covering treatment of depression, anxiety, mood disorders, psychology, pharmacology related to depression. Key topics includes Depression, Anxiety, Mental health, Antidepressants, Emotion, Cognitive, Bipolar disorders, Post traumatic disorder, Postpartum Depression, Suicide. Journal of Depression and Anxiety is a peer reviewed scientific journal known for rapid dissemination of high-quality research. Depression Journal with high impact... Read More

Explore the Current trends in the world of Thyroid Cancer

Image Explore the Current trends in the world of Thyroid Cancer   Thyroid Cancer is a type of cancer that starts in the thyroid gland. Your thyroid is shaped like a small butterfly, and is usually found inside the lower front of your neck. It’s a gland that controls your metabolism. If it’s caught early, thyroid cancer is one of the most treatable forms of cancer. Types of Thyroid Cancer  Researchers have identified four main types: Papillary thyroid cancer. Follicular thyroid cancer Medullary cancer Anaplastic thyroid cancer Thyroid lymphoma. Risk factors Factors that may increase the risk of thyroid... Read More

Chemo and Cancer Therapies: Part 1

Image Chemotherapy: Open Access takes privilege to share the topics related to types of Chemo and Cancer Therapies. Chemotherapy (CMT) is one of the best Open Access journals publishes the relevant and reliable information on the discoveries and current developments in the form of original articles, review articles, case reports, short communications, etc. and all other areas of the field and making them freely available online without any restrictions or any other subscriptions to researchers worldwide. Let’s take a look at different types of Cancer Therapy systems: Cancer Therapies Cancer Therapies are those which are used to treat... Read More

Advanced treatments in Chemotherapy

Image A vast body of research, collected over decades, has confirmed that chemotherapy (or radiotherapy) alone is not sufficient to destroy neoplastic lesions completely. The standard routine now implemented in most hospitals is that of combining chemotherapy and/or radiotherapy alongside immunotherapies. In essence, immunochemotherapy refers to the treatment and management of disease by combining immunotherapy with chemotherapy. The goal of this combination is to improve the treatment outcome for patients with cancer by allowing for a reduction in drug dosage required to combat the cancerous cells. Through supporting a reduced drug dosage, this combination therapy can decrease the... Read More

New Therapies and Immunological Findings in Melanoma and other Skin Cancers

Image Now-a-days, dermatologists and immunologists are striving hard to develop new therapies in the field of skin cancer. In particular, immunological findings have led to the development of highly effective immune-checkpoint inhibitors for cancer. Hence, they are being highlighted and improvised in the field of skin cancer treatment. The purpose of this Research Topic is therefore to provide an up-to-date overview of immune processes and new therapies for melanoma and other skin cancers in order to further stimulate the development of new and even more successful treatments. Journal of Clinical & Experimental Dermatology Research are welcoming experts in... Read More

Journal of Enzyme Engineering Celebrating its Success Journey of 8 years By Annunciating Discounts on Article Processing Charges

Image Enzymes are known to catalyse more than 5,000 biochemical reaction types. Other biocatalysts are catalytic RNA molecules, called ribozymes. Enzymes' specificity comes from their unique three-dimensional structures. Like all catalysts, enzymes increase the reaction rate by lowering its activation energy. Some enzymes can make their conversion of substrate to product occur many millions of times faster. An extreme example is orotidine 5'-phosphate decarboxylase, which allows a reaction that would otherwise take millions of years to occur in milliseconds. Our Journal Enzyme Engineering (Longdom Publishers SL) is an esteemed Monthly, Peer reviewed and Open-Access journal that focuses on recent innovative inventions and recent advancements in the field... Read More

Engineering Practices in Enzymes in Daily Life

Image Enzymes are both proteins and biological catalysts (biocatalysts). Catalysts accelerate chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products. Almost all metabolic processes in the cell need enzyme catalysis in order to occur at rates fast enough to sustain life. Metabolic pathways depend upon enzymes to catalyse individual steps. The study of enzymes is called enzymology and a new field of pseudo enzyme analysis has recently grown up, recognising that during evolution, some enzymes have lost the ability to carry out biological catalysis, which is often reflected in their amino acid sequences and unusual 'pseudo catalytic' properties. Our Journal Enzyme Engineering (Longdom Publishers SL) is... Read More

Challenges of Acne and Rosacea Treatment

Image On behalf of the Journal of Clinical & Experimental Dermatology Research, as Editor-in-Chief, it is my distinct honor and privilege to inform you that, it’s been ten long years we have started the Journal and now we are celebrating the 10th Anniversary and it is my great pleasure and honor to welcome you to the Journal of Clinical & Experimental Dermatology Research. Journal of Clinical & Experimental Dermatology Research aims to disseminate knowledge and promote discussion through the publication of peer-reviewed, high quality research papers on all topics related to Dermatology. The open access journal is published... Read More

Journal of Forensic Biomechanics would like to celebrate its thanksgiving by Providing High Discounts on APC

Image Journal of Forensic Biomechanics is a peer-reviewed scholarly journal and aims to publish the most complete and reliable source of information on the discoveries and current developments in the mode of original articles, review articles, case reports, short communications, etc. covering forensic biomechanics, Computer Forensics, sports medicine, Forensic Accounting, Forensic Assessment, head injury problems, Forensic investigation, biological material properties, Forensic Statistics, biodynamic modeling, forensic epidemiology. Quick publication and open discussion will enhance the clarity and information dissemination of a... Read More

Advanced Techniques in Biology & Medicine-Successful Journey

Image Advanced Techniques in Biology & Medicine has effectively finished its seven volumes and effectively going into the eightby 2020. On this event we heart completely welcome researchers, academicians, students and research scholars to distribute their exploration discoveries as Research articles, Case reports, Reviews, Perspectives, Short editorials and so on., towards this Journal at most elevated potential limits and top tier services. The journal has taken solid goals to serve its readers and writers by incorporating the top tier publicizing methodologies to improve the writer's insightful perceivability and intelligibility. Having set up in the year 2013,"Advanced Techniques in... Read More

On Completing Decade of Successful Publishing Journal of Vascular Medicine & Surgery Announces Special Issue Invitation

Image Journal of Vascular Medicine & Surgery (ISSN: 2329-6925) is scheduled to celebrate its 7th anniversary in the year 2020. The Journal has successfully released several issues of peer-reviewed articles collated from wide geographic locations across the world since its inception in the year 2013, in addition to several special issues and International conference proceedings. To commemorate the decade long publications services, the editorial team of the journal is planning to compile an edited special issue focusing on tending research activities Vascular Medicine & Surgery. The theme/title of the upcoming special issue is Vascular Imaging and Diagnostics, which is... Read More

More you should know about Chemotherapy: Open Access

Image Chemotherapy: Open Access takes privilege to share information with our readers about our Editorial Board members along with First and foremost Editor-in-Chief Tetsuya Konishi Professor, Department of Functional and Analytical Food Sciences. Niigata University of Pharmacy & Applied Life Sciences, Japan. Who is supporting and contributing his valuable time since long time with our Journal. Chemotherapy: Open Access Journal is honour to speak more few words about ditor-in-Chief Tetsuya Konishi, He was graduated from Tokyo College of Pharmacy. AZer completing his graduate study, he worked on radioactive tracer in drug metabolism as a research assistant at Physical... Read More

Let’s have a look at Chemotherapy: Open Access

Image Chemotherapy: Open Access is an Open Access journal that aims to publish quality articles by following stringent peer review process. The main motto of the journal is to disseminate the research knowledge worldwide shared by the Scientific Experts in the form of Research Article, Review Article, Case reports, Short Commentary, etc. The purpose of publishing excellent research information is to create a huge impact on aspiring researcher across the globe. Chemotherapy: Open Access covers a wide range of topics such as Cytotoxic, Electro, and the antimicrobial chemotherapies used to treat several... Read More

Allergy and Therapy announces International Collaborations with Research Institutes and Universities.

Image Allergy and Therapy announces International Collaborations with Research Institutes and Universities. In line with development of friendly international cooperation, Journal of Allergy and Therapy wishes to establish a long-term mutually beneficial collaboration with various Institution/University by accepting bulk submissions in the field of Allergy at a highly reduced processing fee. The ever growing pollution and lifestyle changes have caused allergic responses a regular issue especially in the urban life of human being. Considerate of this fact Journal of Allergy and Therapy (JAT) presents a spectrum of exciting information on various approaches adopted and their... Read More

Know Allergy for No Allergy

Image Know Allergy for No Allergy The Journal of Allergy & Therapy presents a spectrum of exciting information on various approaches adopted and their possible outcomes in allergy research including new strategies in diagnosis, therapy and prevention of allergic diseases. Journal of Allergy & Therapy has collaborated with numerous conferences to enable the publishing of extended versions of the abstracts presented at the conference. Various Conferences like 12th International Conference on Allergy, Asthma & Clinical Immunology. 13th International Conference on Allergy and Clinical Immunology and World Congress on Allergy and Immunotherapy have been associated with... Read More

Innovative Enzyme Engineering For A Better Health In Clinical Sciences

Image Our Journal Enzyme Engineering (Longdom Publishers SL) is an esteemed Monthly, Peer reviewed and Open-Access journal that focuses on recent innovative inventions and recent advancements in the field of enzymology and enzyme engineering. Our journal promulgates all current issues that take place in betterment in the field of Life sciences. The Editorial Board of our journal is overwhelmed by the response and eagerness of the academic and research contributors to publish with the journal and take part in the year-long celebrations. During this year we look forward to taking some initiatives that would encourage... Read More

Enzyme Engineering For A Better Tomorrow In World Of Health

Image                                                                                          On behalf of our esteemed journal Enzyme Engineering (Longdom Publishers SL) is a scientific open access journal that specifies and describes the development activities conducted in the field of Medical Science. The objective of the journal is to provide a medium for scientific communication to confer about the recent advancements in Enzymology. The... Read More

Treatment advances in Dermatology and Trichology

Image Dermatology is a discipline of medical science that deals with the dermal, skin diseases and associated treatment regime. Clinical practices in relation to dermatology embrace several sub disciplines including Dermatitis, Cosmetic dermatology, Dermatopathology, Immunodermatology, Pediatric dermatology, Cutaneous lymphoma, Lesions, Melanoma, Blisters, etc. Owing to the importance of each sub discipline the Journal of Clinical & Experimental Dermatology Research renders a common platform for the discussion of various important issues. Journal of Clinical & Experimental Dermatology Research supports the scientific innovation and advancement in all related aspects of Skin, Hair and Nail... Read More

On Completing Decade of Successful Publishing Journal of Neonatal Biology Announces Special Issue-Care of the infant affected by Neonatal Abstinence Syndrome

Image Journal of Neonatal Biology (ISSN: 2167-0897) is scheduled to celebrate its 9th anniversary in the year 2020. The monthly journal has successfully released several issues of peer-reviewed articles collated from wide geographic locations across the world since its inception in the year 2012, in addition to several special issues. To commemorate the decade long publications services, the editorial team of the journal is planning to compile an edited special issue focusing on tending research activities in Neonatal. The theme/title of the upcoming special issue is Care of the infant affected by Neonatal Abstinence Syndrome. The main focus... Read More

Endocrinology & Metabolic Syndrome Accomplished 8 Years Milestone in Research Publication Journey

Image Endocrinology & Metabolic Syndrome celebrates its 8 years of existence in the field of medical research publication and extends a very warm welcome to all the authors, researchers, editors and students across the world to contribute their latest research findings as full-length articles to this collaborative medical journal. Endocrinology & Metabolic Syndrome started in the year 2011 and now established as one of the most reputed journals of LONGDOM publishing group, a collaborative medical publisher, known for its close-knit association with medical societies and agencies engaged in medical research. The journal has been publishing the most recent developments... Read More