Enzyme Enabled Antibiotic Production
Manufacturing is the life line and driver of economic development; by producing goods we not only achieve growth but also vastly improve our quality of life. Manufacturing in simple terms means taking certain raw materials and converting them into value added products and invariably nuisance value by-products or creating eco-impact at various levels and with more. In addition, consumption of the key material from the nature depletes the same and without a concerted eco-responsible effort the natural resource is lost for ever.
Enabling Sustainability A paradigm shift in manufacturing mind-set, defined figuratively as “Green manufacturing” has emerged as a trend in developed economics, though at various levels of successful translation across various geographies. Green manufacturing may be generically defined as “elimination of waste by re-defining the existing production system” which is achieved by adhering to various smarter, benign and ecoefficient strategies. These strategies aim at making products/processes which consume less input, less energy, substitution chemistry (from toxic input to non-toxic input, from non-renewable input to renewable input), reducing unwanted outputs, converting outputs into inputs (recycling) or use of ‘smart enzymes” to transform the way the chemicals are manufactured.
Antibiotics Manufacture: Main driver for “Green” Make Over
Green manufacturing approaches in pharmaceuticals assumes prime importance due to its sheer size as well as the overall alleviation effect it potentially brings to already stressed environmentally non-benign chemical process. Apart from reducing the pollution footprint and being cost effective, green approaches leads to cleaner manufacturing shop floors, more purer final products with virtually no impurity carry over and thus reducing the both occupational and consumption health risk perspectives.
Moreover, over the years the efficiency of chemical manufacturing process has reached stagnation without further scope for improvement in terms of process times, yield and purity or in some cases conventional chemistry options were limited or non-existent, which necessitated the transformation into more smarter approaches. One of the most exciting, promising, innovative ways that this can be achieved is to use nature’s catalysts (i.e. enzymes) to perform chemical reactions more efficiently, and most importantly, under mild conditions which have minimal environmental burden.
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