Clinical Validation and Diagnostic Utility of Optical Genome Mapping in Prenatal Diagnostic Testing


Fluorescence in situ hybridization (FISH) is a sensitive method for detecting small genomic alterations associated with a variety of hematological malignancies and solid tumors. FISH technology has several advantages over routine chromosomal analysis; such advantages include its ability to detect genomic abnormalities in non-viable and non-meristematic tissues, rapid turnaround times, and more Includes high resolution. However, FISH technology complements routine chromosome analysis and does not replace routine chromosome analysis for cancer diagnosis. One of the major limitations in aquaculture production is the susceptibility of farmed fish to diseases due to livestock practices and external factors such as pollution, climate change, and even changes in the dynamics of product trade in this industry. However, it is important to better understand and characterize the participants in the course of disease development. This is because they cause enormous economic losses to the aquaculture industry. High-throughput techniques such as proteomics are important characterization tools, especially in pathogen identification and virulence mechanisms related to host-pathogen interactions in disease research and diagnosis that aid in the control, prevention, and treatment of disease in farmed fish. It may become. The critical role of proteomics is also maximized by a holistic approach to understanding pathogenic processes and fish responses to external factors such as stress and temperature. The purpose of this review is to provide the reader with a state-of-the-art description of farmed fish pathologies and the major factors affecting their diagnosis. Of particular focus is the use of proteomic technologies as tools in assessing pathogens and host-pathogen interactions and their impact on disease characterization and control. Researchers around the world have found that eating fish regularly — one her serving or two her servings a week — can reduce the risk of diseases ranging from childhood asthma to prostate cancer. Fish is low in fat, high in protein and a good source of omega-3 fatty acids. Selected studies suggest: Asthma - Children who eat fish are less likely to develop asthma. Cancer the omega-3 fatty acids found in fish can contribute to the health of many types of cancer, especially oral, esophageal, colon, breast, ovarian, it can reduce the risk of prostate cancer by 30-50%. Cardiovascular disease - Eating fish weekly reduces blood clots and inflammation, improves blood vessel elasticity, and lowers blood pressure, lowers blood fat, and increases "good" cholesterol, thus reducing the risk of heart disease and stroke. Older people with dementia who eat seafood more than once a week may have a lower risk of developing dementia, including Alzheimer's disease. Depression People who eat fish regularly are less likely to develop depression (depression is associated with low levels of omega-3 fatty acids in the brain). Diabetic fish helps diabetics control blood sugar levels. Vision Breastfed babies born to mothers who eat fish have better eyesight, presumably due to the omega-3 fatty acids that pass into breast milk. Inflammatory Conditions Regular consumption of fish can reduce the symptoms of rheumatoid arthritis, psoriasis and autoimmune diseases. Eating fish during pregnancy can reduce the risk of premature birth. Healthy ways to enjoy fish include baking, poaching, grilling, and steaming.